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Sex difference in the effect of the fasting serum glucose level on the risk of coronary heart disease

Authors
 Song Vogue Ahn  ;  Hyeon Chang Kim  ;  Chung Mo Nam  ;  Il Suh 
Citation
 Journal of Cardiology, Vol.71(2) : 149-154, 2018 
Journal Title
 Journal of Cardiology 
ISSN
 0914-5087 
Issue Date
2018
MeSH
Adult ; Blood Glucose/analysis* ; Coronary Disease/blood* ; Fasting/blood* ; Female ; Humans ; Male ; Middle Aged ; Prediabetic State/blood* ; Proportional Hazards Models ; Risk Factors ; Sex Characteristics
Keywords
Coronary heart disease ; Diabetes mellitus ; Glucose ; Prospective study ; Women
Abstract
OBJECTIVE: Diabetic women have a greater relative risk of coronary heart disease than diabetic men. However, the sex difference in the effect of fasting serum glucose levels below the diabetic range on the risk of coronary heart disease is unclear. We investigated whether the association between nondiabetic blood glucose levels and the incident risk of coronary heart disease is different between men and women. METHODS: The fasting serum glucose levels and other cardiovascular risk factors at baseline were measured in 159,702 subjects (100,144 men and 59,558 women). Primary outcomes were hospital admission and death due to coronary heart disease during the 11-year follow-up. RESULTS: The risk for coronary heart disease in women significantly increased with impaired fasting glucose levels (≥110mg/dL) compared to normal glucose levels (<100mg/dL), whereas the risk for coronary heart disease in men was significantly increased at a diabetic glucose range (≥126mg/dL). Women had a higher hazard ratio of coronary heart disease associated with the fasting serum glucose level than men (p for interaction with sex=0.021). CONCLUSIONS: The stronger effect of the fasting serum glucose levels on the risk of coronary heart disease in women than in men was significant from a prediabetic range (≥110mg/dL).
Full Text
https://www.sciencedirect.com/science/article/pii/S0914508717302137
DOI
10.1016/j.jjcc.2017.07.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
김현창(Kim, Hyeon Chang) ORCID logo https://orcid.org/0000-0001-7867-1240
남정모(Nam, Jung Mo) ORCID logo https://orcid.org/0000-0003-0985-0928
서일(Suh, Il) ORCID logo https://orcid.org/0000-0002-9689-7849
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161789
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