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Meibomian Gland Dysfunction Associated With Periocular Radiotherapy

Authors
 Woo Young Jun  ;  Ko JaeSang  ;  Ji Yong Woo  ;  Kim Tae-im  ;  Yoon Jin Sook 
Citation
 Cornea, Vol.36(12) : 1486-1491, 2017 
Journal Title
 Cornea 
ISSN
 0277-3740 
Issue Date
2017
Keywords
Adult ; Age Factors ; Aged ; Case-Control Studies ; Conjunctival Neoplasms/physiopathology ; Conjunctival Neoplasms/radiotherapy* ; Dry Eye Syndromes/etiology ; Eyelid Diseases/etiology* ; Eyelid Diseases/physiopathology ; Female ; Humans ; Lymphoma/physiopathology ; Lymphoma/radiotherapy* ; Male ; Meibomian Glands/physiopathology* ; Middle Aged ; Orbital Neoplasms/physiopathology ; Orbital Neoplasms/radiotherapy* ; Radiation Dosage ; Radiation Injuries/physiopathology* ; Radiotherapy/adverse effects* ; Radiotherapy/methods ; Tears/physiology
Abstract
PURPOSE: To investigate the influence of periocular radiotherapy on meibomian glands. METHODS: We evaluated 28 patients (40 eyes) who received radiotherapy (RT group) for conjunctival or orbital lymphoma and 30 age-matched control subjects (60 eyes). Subjects underwent slit-lamp examination of the eyelids, Schirmer test, meibography, and evaluation of tear film breakup time (TBUT), Ocular Surface Disease Index (OSDI) scores, meibomian glands evaluation (meiboscore, meibum expressibility, and lid margin abnormality scores), and tear film lipid layer thickness using an ocular surface interferometer. These parameters were compared between subjects in the RT and control groups. RESULTS: Meiboscores as well as meibum expressibility and OSDI scores in the RT group were significantly higher compared with those in the control group (1.6 ± 0.9 vs. 0.4 ± 0.6, 1.6 ± 1.0 vs. 0.2 ± 0.4, and 48.1 ± 21.4 vs. 6.2 ± 4.4, respectively, P < 0.001, all), whereas the Schirmer value (9.2 ± 5.1 vs. 12.3 ± 5.2, P = 0.004), TBUT (4.2 ± 2.5 vs. 6.4 ± 2.6, P = 0.001), and lipid layer thickness (61.0 ± 29.3 vs. 85.2 ± 20.0, P < 0.001) in the RT group were lower compared with those in the control group. The percentage of meibomian gland dropout was significantly correlated with age (P = 0.025) and total radiation dose (P = 0.012), regardless of the target location of irradiation. Even low-dose irradiated eyes (<30 Gy) exhibited significantly higher meiboscores (P < 0.001) and shorter TBUT (P = 0.005) compared with control eyes. CONCLUSIONS: Eyes that received periocular radiotherapy exhibited relatively high tear film instability induced by meibomian gland dysfunction, contributing to the high severity of dry eye symptoms.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003226-201712000-00007&LSLINK=80&D=ovft
DOI
10.1097/ICO.0000000000001377
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
고재상(Ko, Jaesang) ORCID logo https://orcid.org/0000-0002-3011-7213
김태임(Kim, Tae Im) ORCID logo https://orcid.org/0000-0001-6414-3842
윤진숙(Yoon, Jin Sook) ORCID logo https://orcid.org/0000-0002-8751-9467
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161738
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