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Effect of accelerated corneal crosslinking combined with transepithelial photorefractive keratectomy on dynamic corneal response parameters and biomechanically corrected intraocular pressure measured with a dynamic Scheimpflug analyzer in healthy myopic patients

Authors
 Hun Lee  ;  Cynthia J. Roberts  ;  Renato Ambrósio Jr.  ;  Ahmed Elsheikh  ;  David Sung Yong Kang  ;  Tae-im Kim 
Citation
 JOURNAL OF CATARACT AND REFRACTIVE SURGERY, Vol.43(7) : 937-945, 2017 
Journal Title
 JOURNAL OF CATARACT AND REFRACTIVE SURGERY 
ISSN
 0886-3350 
Issue Date
2017
Abstract
PURPOSE: To evaluate the effect of accelerated corneal crosslinking (CXL) combined with transepithelial photorefractive keratectomy (PRK) on changes in new dynamic corneal response parameters and the biomechanically corrected intraocular pressure (IOP) measured using a dynamic Scheimpflug analyzer (Corvis ST). SETTING: Yonsei University College of Medicine and Eyereum Eye Clinic, Seoul, South Korea. DESIGN: Retrospective case series. METHODS: Medical records of eyes of healthy myopic patients having transepithelial PRK or transepithelial PRK with CXL were examined. Main outcome variables were the biomechanically corrected IOP and new dynamic corneal response parameters including the deformation amplitude ratio at 1.0 mm (DAR1) and at 2.0 mm (DAR2), stiffness at first applanation and at highest concavity, and the integrated inverse radius preoperatively and 6 months postoperatively. RESULTS: The study comprised 69 eyes (69 patients); 35 had transepithelial PRK and 34, transepithelial PRK with CXL. The DAR1, DAR2, and integrated inverse radius significantly increased, while stiffness at first applanation and at highest concavity decreased postoperatively in both groups. Changes in the DAR2 and integrated inverse radius in the transepithelial PRK group were significantly larger than in the transepithelial PRK with CXL group without and with analysis of covariance with the spherical equivalent change or corneal thickness change as a covariate. No significant differences in the biomechanically corrected IOP occurred preoperatively or postoperatively in either group. CONCLUSIONS: Results indicate that prophylactic CXL combined with transepithelial PRK has a role in reducing the change in corneal biomechanical properties. The dynamic Scheimpflug analyzer showed stable biomechanically corrected IOP measurements preoperatively and postoperatively.
Full Text
https://www.sciencedirect.com/science/article/pii/S0886335017304133
DOI
10.1016/j.jcrs.2017.04.036
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161708
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