16 34

Cited 0 times in

Effectiveness of atrial fibrillation rotor ablation is dependent on conduction velocity: An in-silico 3-dimensional modeling study.

Authors
 Byounghyun Lim  ;  Minki Hwang  ;  Jun-Seop Song  ;  Ah-Jin Ryu  ;  Boyoung Joung  ;  Eun Bo Shim  ;  Hyungon Ryu  ;  Hui-Nam Pak 
Citation
 PLoS One, Vol.12(12) : e0190398, 2017 
Journal Title
 PLoS One 
Issue Date
2017
MeSH
Aged ; Algorithms ; Atrial Fibrillation/surgery* ; Catheter Ablation/instrumentation ; Catheter Ablation/methods* ; Computer Simulation ; Female ; Humans ; Male ; Middle Aged
Abstract
BACKGROUND: We previously reported that stable rotors are observed in in-silico human atrial fibrillation (AF) models, and are well represented by a dominant frequency (DF). In the current study, we hypothesized that the outcome of DF ablation is affected by conduction velocity (CV) conditions and examined this hypothesis using in-silico 3D-AF modeling. METHODS: We integrated 3D CT images of left atrium obtained from 10 patients with persistent AF (80% male, 61.8±13.5 years old) into in-silico AF model. We compared AF maintenance durations (max 300s), spatiotemporal stabilities of DF, phase singularity (PS) number, life-span of PS, and AF termination or defragmentation rates after virtual DF ablation with 5 different CV conditions (0.2, 0.3, 0.4, 0.5, and 0.6m/s). RESULTS: 1. AF maintenance duration (p<0.001), spatiotemporal mean variance of DF (p<0.001), and the number of PS (p = 0.023) showed CV dependent bimodal patterns (highest at CV0.4m/s and lowest at CV0.6m/s) consistently. 2. After 10% highest DF ablation, AF defragmentation rates were the lowest at CV0.4m/s (37.8%), but highest at CV0.5 and 0.6m/s (all 100%, p<0.001). 3. In the episodes with AF termination or defragmentation followed by 10% highest DF ablation, baseline AF maintenance duration was shorter (p<0.001), spatiotemporal mean variance of DF was lower (p = 0.014), and the number of PS was lower (p = 0.004) than those with failed AF defragmentation after DF ablation. CONCLUSION: Virtual ablation of DF, which may indicate AF driver, was more likely to terminate or defragment AF with spatiotemporally stable DF, but not likely to do so in long-lasting and sustained AF conditions, depending on CV.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161644
DOI
10.1371/journal.pone.0190398
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
박희남(Pak, Hui Nam) ; 임병현(Lim, Byounghyun) ; 정보영(Joung, Bo Young)
사서에게 알리기
  feedback
Files in This Item:
T201705434.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse