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Effectiveness of atrial fibrillation rotor ablation is dependent on conduction velocity: An in-silico 3-dimensional modeling study.

DC FieldValueLanguage
dc.contributor.author박희남-
dc.contributor.author임병현-
dc.contributor.author정보영-
dc.date.accessioned2018-07-20T12:01:06Z-
dc.date.available2018-07-20T12:01:06Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161644-
dc.description.abstractBACKGROUND: We previously reported that stable rotors are observed in in-silico human atrial fibrillation (AF) models, and are well represented by a dominant frequency (DF). In the current study, we hypothesized that the outcome of DF ablation is affected by conduction velocity (CV) conditions and examined this hypothesis using in-silico 3D-AF modeling. METHODS: We integrated 3D CT images of left atrium obtained from 10 patients with persistent AF (80% male, 61.8±13.5 years old) into in-silico AF model. We compared AF maintenance durations (max 300s), spatiotemporal stabilities of DF, phase singularity (PS) number, life-span of PS, and AF termination or defragmentation rates after virtual DF ablation with 5 different CV conditions (0.2, 0.3, 0.4, 0.5, and 0.6m/s). RESULTS: 1. AF maintenance duration (p<0.001), spatiotemporal mean variance of DF (p<0.001), and the number of PS (p = 0.023) showed CV dependent bimodal patterns (highest at CV0.4m/s and lowest at CV0.6m/s) consistently. 2. After 10% highest DF ablation, AF defragmentation rates were the lowest at CV0.4m/s (37.8%), but highest at CV0.5 and 0.6m/s (all 100%, p<0.001). 3. In the episodes with AF termination or defragmentation followed by 10% highest DF ablation, baseline AF maintenance duration was shorter (p<0.001), spatiotemporal mean variance of DF was lower (p = 0.014), and the number of PS was lower (p = 0.004) than those with failed AF defragmentation after DF ablation. CONCLUSION: Virtual ablation of DF, which may indicate AF driver, was more likely to terminate or defragment AF with spatiotemporally stable DF, but not likely to do so in long-lasting and sustained AF conditions, depending on CV.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAlgorithms-
dc.subject.MESHAtrial Fibrillation/surgery*-
dc.subject.MESHCatheter Ablation/instrumentation-
dc.subject.MESHCatheter Ablation/methods*-
dc.subject.MESHComputer Simulation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.titleEffectiveness of atrial fibrillation rotor ablation is dependent on conduction velocity: An in-silico 3-dimensional modeling study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorByounghyun Lim-
dc.contributor.googleauthorMinki Hwang-
dc.contributor.googleauthorJun-Seop Song-
dc.contributor.googleauthorAh-Jin Ryu-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorEun Bo Shim-
dc.contributor.googleauthorHyungon Ryu-
dc.contributor.googleauthorHui-Nam Pak-
dc.identifier.doi10.1371/journal.pone.0190398-
dc.contributor.localIdA01776-
dc.contributor.localIdA05396-
dc.contributor.localIdA03609-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid29287119-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameLim, Byounghyun-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorLim, Byounghyun-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.citation.volume12-
dc.citation.number12-
dc.citation.startPagee0190398-
dc.identifier.bibliographicCitationPLOS ONE, Vol.12(12) : e0190398, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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