Cited 18 times in
Effectiveness of atrial fibrillation rotor ablation is dependent on conduction velocity: An in-silico 3-dimensional modeling study.
DC Field | Value | Language |
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dc.contributor.author | 박희남 | - |
dc.contributor.author | 임병현 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2018-07-20T12:01:06Z | - |
dc.date.available | 2018-07-20T12:01:06Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161644 | - |
dc.description.abstract | BACKGROUND: We previously reported that stable rotors are observed in in-silico human atrial fibrillation (AF) models, and are well represented by a dominant frequency (DF). In the current study, we hypothesized that the outcome of DF ablation is affected by conduction velocity (CV) conditions and examined this hypothesis using in-silico 3D-AF modeling. METHODS: We integrated 3D CT images of left atrium obtained from 10 patients with persistent AF (80% male, 61.8±13.5 years old) into in-silico AF model. We compared AF maintenance durations (max 300s), spatiotemporal stabilities of DF, phase singularity (PS) number, life-span of PS, and AF termination or defragmentation rates after virtual DF ablation with 5 different CV conditions (0.2, 0.3, 0.4, 0.5, and 0.6m/s). RESULTS: 1. AF maintenance duration (p<0.001), spatiotemporal mean variance of DF (p<0.001), and the number of PS (p = 0.023) showed CV dependent bimodal patterns (highest at CV0.4m/s and lowest at CV0.6m/s) consistently. 2. After 10% highest DF ablation, AF defragmentation rates were the lowest at CV0.4m/s (37.8%), but highest at CV0.5 and 0.6m/s (all 100%, p<0.001). 3. In the episodes with AF termination or defragmentation followed by 10% highest DF ablation, baseline AF maintenance duration was shorter (p<0.001), spatiotemporal mean variance of DF was lower (p = 0.014), and the number of PS was lower (p = 0.004) than those with failed AF defragmentation after DF ablation. CONCLUSION: Virtual ablation of DF, which may indicate AF driver, was more likely to terminate or defragment AF with spatiotemporally stable DF, but not likely to do so in long-lasting and sustained AF conditions, depending on CV. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Algorithms | - |
dc.subject.MESH | Atrial Fibrillation/surgery* | - |
dc.subject.MESH | Catheter Ablation/instrumentation | - |
dc.subject.MESH | Catheter Ablation/methods* | - |
dc.subject.MESH | Computer Simulation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.title | Effectiveness of atrial fibrillation rotor ablation is dependent on conduction velocity: An in-silico 3-dimensional modeling study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Byounghyun Lim | - |
dc.contributor.googleauthor | Minki Hwang | - |
dc.contributor.googleauthor | Jun-Seop Song | - |
dc.contributor.googleauthor | Ah-Jin Ryu | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Eun Bo Shim | - |
dc.contributor.googleauthor | Hyungon Ryu | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.1371/journal.pone.0190398 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A05396 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 29287119 | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Lim, Byounghyun | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Lim, Byounghyun | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.citation.volume | 12 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | e0190398 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.12(12) : e0190398, 2017 | - |
dc.identifier.rimsid | 61667 | - |
dc.type.rims | ART | - |
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