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Pro-tumorigenic roles of TGF-β signaling during the early stages of liver tumorigenesis through upregulation of Snail

Authors
 Hyuk Moon  ;  Kwang-Hyub Han  ;  Simon Weonsang Ro 
Citation
 BMB Reports, Vol.50(12) : 599-600, 2017 
Journal Title
 BMB Reports 
ISSN
 1976-6696 
Issue Date
2017
MeSH
Cancer model ; Hepatocellular carcinoma ; Snail ; Transforming growth factor β (TGF-β) ; Tumor promotion
Abstract
Many studies have focused on the tumor suppressive role of TGF-β signaling during the early stages of tumorigenesis by activating the target genes involved in cytostasis and apoptosis. We investigated the effects of TGF-β inhibition on early tumorigenesis in the liver, by employing diverse inhibitory methods. Strikingly, TGF-β inhibition consistently suppressed hepatic tumorigenesis that was induced either by activated RAS plus p53 downregulation or by the co-activation of RAS and TAZ signaling; this demonstrates the requirements for canonical TGF-β signaling in tumorigenesis. Moreover, we found that Snail is the target gene of the TGF-β signaling pathway that promotes hepatic carcinogenesis. The knockdown of Snail suppressed the early tumorigenesis in the liver, as did the TGF-β inhibition, while the ectopic expression of Snail restored tumorigenesis that was suppressed by the TGF-β inhibition. Our findings establish the oncogenic TGF-β-Smad- Snail signaling axis during the early tumorigenesis in the liver.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161642
DOI
10.5483/BMBRep.2017.50.12.201
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute of Gastroenterology (소화기병연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
노원상(Ro, Simon Weonsang) ; 한광협(Han, Kwang Hyup)
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