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Bone Regeneration Using N-Methyl-2-pyrrolidone as an Enhancer for Recombinant Human Bone Morphogenetic Protein-2 in a Rabbit Sinus Augmentation Model

Authors
 Hyun-Chang Lim  ;  Daniel S. Thoma  ;  So-Ra Yoon  ;  Jae-Kook Cha  ;  Jung-Seok Lee  ;  Ui-Won Jung 
Citation
 BioMed Research International, Vol.2017 : 4153073, 2017 
Journal Title
 BioMed Research International 
ISSN
 2314-6133 
Issue Date
2017
MeSH
Animals ; Bone Regeneration/drug effects* ; Dose-Response Relationship, Drug ; Humans ; Matrix Metalloproteinase 2/pharmacology* ; Pyrrolidinones/pharmacology* ; Rabbits ; Recombinant Proteins/pharmacology ; Sinus Floor Augmentation/methods*
Abstract
The aim of this study was to determine whether N-methyl-2-pyrrolidone (NMP) can decrease the dose of recombinant human bone morphogenetic protein-2 (rhBMP-2) in sinus augmentation of rabbits. In each of 15 rabbits, 2 sinuses were randomly grafted using 1 of 3 treatment modalities: (i) biphasic calcium phosphate (BCP; control), (ii) rhBMP-2-coated BCP (BMP), or (iii) rhBMP-2-coated BCP soaked in NMP solution (BMP/NMP). The rabbits were sacrificed 2 weeks postoperatively. Histologic and histomorphometric analyses were performed. Bone formation in all groups was predominantly located close to the access window and the lateral walls. Newly formed bone within the total augmented area (NBTA) was greatest in BMP/NMP (1.94 ± 0.69 mm2), followed by BMP (1.50 ± 0.72 mm2) and BCP (1.28 ± 0.52 mm2) (P > 0.05). In the center of the augmentation (NBROI_C) and the area close to the sinus membrane (NBROI_M), BMP/NMP produced the largest area of NB (NBROI_C: 0.10 ± 0.11 mm2; NBROI_M: 0.17 ± 0.08 mm2); the corresponding NB values for BCP were 0.05 ± 0.05 mm2 and 0.08 ± 0.09 mm2, respectively (P > 0.05 for all comparisons). The effect of NMP on bone regeneration was inconsistent between the specimens. Adding NMP as an adjunct to rhBMP-2-coated BCP produced inconsistent effects on bone regeneration, resulting in no significant benefit compared to controls.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161620
DOI
10.1155/2017/4153073
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실)
Yonsei Authors
이중석(Lee, Jung Seok) ; 정의원(Jung, Ui Won) ; 차재국(Cha, Jae Kook)
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