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Biology of invasive mucinous adenocarcinoma of the lung.

Authors
 Yoon Jin Cha  ;  Hyo Sup Shim 
Citation
 Translational Lung Cancer Research, Vol.6(5) : 508-512, 2017 
Journal Title
 Translational Lung Cancer Research 
Issue Date
2017
Keywords
Lung cancer ; adenocarcinoma ; biology ; genetics ; mucinous
Abstract
Invasive mucinous adenocarcinoma (IMA) is a unique histologic subtype of lung adenocarcinoma. Recent studies document distinctive genetic alterations (e.g., NRG1 fusions) and a "mucinous gene signature" in IMAs, as well as differences in clinical responses to traditional chemotherapies in IMAs versus non-mucinous adenocarcinomas. Our understanding of the genetic and clinical characteristics of IMAs has expanded, confirming the uniqueness of IMAs. Accordingly, IMAs require different therapeutic approaches than do lung adenocarcinomas in general. Here, we review recent updates on the genetic and clinical profiles of IMA of the lung.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161616
DOI
10.21037/tlcr.2017.06.10
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
심효섭(Shim, Hyo Sup)
차윤진(Cha, Yoon Jin)
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