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Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea

Authors
 In Young Jung  ;  Jung Ju Kim  ;  Se Ju Lee  ;  Jinnam Kim  ;  Hye Seong  ;  Wooyong Jeong  ;  Heun Choi  ;  Su Jin Jeong  ;  Nam Su Ku  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Young Goo Song  ;  Jung Won Park  ;  June Myung Kim 
Citation
 BioMed Research International, Vol.2017 : 4304973, 2017 
Journal Title
 BioMed Research International 
ISSN
 2314-6133 
Issue Date
2017
Abstract
Background: Adverse drug reactions (ADRs) are any unwanted/uncomfortable effects from medication resulting in physical, mental, and functional injuries. Antibiotics account for up to 40.9% of ADRs and are associated with several serious outcomes. However, few reports on ADRs have evaluated only antimicrobial agents. In this study, we investigated antibiotic-related ADRs at a tertiary care hospital in South Korea. Methods: This is a retrospective cohort study that evaluated ADRs to antibiotics that were reported at a 2400-bed tertiary care hospital in 2015. ADRs reported by physicians, pharmacists, and nurses were reviewed. Clinical information reported ADRs, type of antibiotic, causality assessment, and complications were evaluated. Results: 1,277 (62.8%) patients were considered antibiotic-related ADRs based on the World Health Organization-Uppsala Monitoring Center criteria (certain, 2.2%; probable, 35.7%; and possible, 62.1%). Totally, 44 (3.4%) patients experienced serious ADRs. Penicillin and quinolones were the most common drugs reported to induce ADRs (both 16.0%), followed by third-generation cephalosporins (14.9%). The most frequently experienced side effects were skin manifestations (45.1%) followed by gastrointestinal disorders (32.6%). Conclusion: Penicillin and quinolones are the most common causative antibiotics for ADRs and skin manifestations were the most frequently experienced symptom.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161563
DOI
10.1155/2017/4304973
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
구남수(Ku, Nam Su) ; 김정주(Kim, Jung Ju) ; 김준명(Kim, June Myung) ; 김진남(Kim, Jin Nam) ; 박중원(Park, Jung Won) ; 송영구(Song, Young Goo) ; 정수진(Jeong, Su Jin) ; 정우용(Jeong, Wooyong) ; 정인영(Jung, In Young) ; 최준용(Choi, Jun Yong) ; 최흔(Choi, Heun) ; 한상훈(Han, Sang Hoon)
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