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Association between changes in systolic blood pressure and incident diabetes in a community-based cohort study in Korea

Authors
 Seung Won Lee  ;  Hyeon Chang Kim  ;  Ju-mi Lee  ;  Young Mi Yun  ;  Joo Young Lee  ;  Il Suh 
Citation
 Hypertension Research, Vol.40(7) : 710-716, 2017 
Journal Title
 Hypertension Research 
ISSN
 0916-9636 
Issue Date
2017
MeSH
Adult ; Aged ; Aged, 80 and over ; C-Reactive Protein/analysis ; Cohort Studies ; Diabetes Mellitus/etiology* ; Female ; Humans ; Hypertension/complications* ; Insulin Resistance ; Male ; Middle Aged ; Systole/physiology* ; Young Adult
Abstract
An association between hypertension and diabetes has been reported; however, the temporal relationship of blood pressure changes and incident diabetes has not been fully investigated in the general population. We examined whether increasing blood pressure is associated with the risk of developing diabetes among community-dwelling Korean adults. This study included 2225 participants (859 men and 1366 women) aged 27-87 years from the Korean Genome Epidemiology Study. The participants were free of diabetes and cardiovascular disease at baseline. Incident diabetes was defined as fasting blood glucose⩾126 mg dl-1 or hemoglobin a1c ⩾6.5% (48 mmol mol-1) at follow-up examination and/or a physician's diagnosis of diabetes during the follow-up period. The effects of the baseline level and change in blood pressure on the risk of incident diabetes were assessed by multivariate logistic regression analysis. During the mean follow-up of 2.6 years, new-onset diabetes was observed in 5.0% (43/859) of the men and 3.4% (47/1366) of the women. In the multivariate model, the baseline systolic blood pressure was not significantly associated with incident diabetes (adjusted odds ratio 0.93 per 10 mmHg, P=0.747). However, an increase in systolic blood pressure during the follow-up period was independently associated with incident diabetes (adjusted odds ratio 5.53 per 5 mmHg per year, P=0.002) after adjusting for the baseline blood pressure and other potential confounders. Increasing blood pressure, but not a high baseline blood pressure, was independently associated with the risk of diabetes in Korean adults.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161555
DOI
10.1038/hr.2017.21
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
Yonsei Authors
김현창(Kim, Hyeon Chang) ; 서일(Suh, Il)
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Full Text
http://www.nature.com/articles/hr201721
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