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Association between high-density lipoprotein cholesterol level and pulmonary function in healthy Korean adolescents: the JS high school study

Authors
 Ji Hye Park  ;  Seyeon Mun  ;  Dong Phil Choi  ;  Joo Young Lee  ;  Hyeon Chang Kim 
Citation
 BMC Pulmonary Medicine, Vol.17(1) : 190, 2017 
Journal Title
 BMC Pulmonary Medicine 
Issue Date
2017
Keywords
Adolescent ; Forced expiratory volume ; Forced vital capacity ; High-density lipoprotein ; Respiratory function tests
Abstract
BACKGROUND: Accumulating evidence suggests that high-density lipoprotein (HDL) cholesterol is associated with pulmonary function and pulmonary disorders. The aim of this study was to evaluate the association between HDL cholesterol and pulmonary function in healthy adolescents. METHODS: This cross-sectional study was based on data collected for the JS High School study. The analysis included 644 adolescents (318 male and 326 female) aged 15-16 years old and free from asthma or chronic obstructive pulmonary disease. Fasting blood samples were collected for hematologic and biochemical assessment. Forced vital capacity volume (FVC) and forced expiratory volume in the 1 s (FEV1) were measured using dry-rolling-seal spirometry. The associations between HDL cholesterol and pulmonary function were analyzed using multiple linear regression models. RESULTS: Among male adolescents, an increase of 1.0 mg/dL in HDL cholesterol was associated with 10 mL decrease in FVC (p = 0.013) and FEV1 (p = 0.013) after adjusting for age, height, weight, alcohol drinking, smoking, physical activity, systolic blood pressure, total cholesterol, triglyceride, and monthly household income. Percent predicted values of FVC (p = 0.036) and FEV1 (p = 0.017) were also inversely associated with HDL cholesterol. However, among female adolescents, HDL cholesterol level was not significantly associated with absolute or percent predictive value of FVC and FEV1. CONCLUSIONS: Higher HDL cholesterol level may be associated with decreased pulmonary function among healthy male adolescents. The sex differences observed in the association between HDL cholesterol and pulmonary function need further investigation.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161514
DOI
10.1186/s12890-017-0548-6
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
Yonsei Authors
김현창(Kim, Hyeon Chang) ; 이주영(Lee, Joo Young)
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