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Anchored protease-activatable polymersomes for molecular diagnostics of metastatic cancer cells

DC FieldValueLanguage
dc.contributor.author손혜영-
dc.contributor.author최지혜-
dc.contributor.author허용민-
dc.date.accessioned2018-07-20T11:55:48Z-
dc.date.available2018-07-20T11:55:48Z-
dc.date.issued2017-
dc.identifier.issn2050-750X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161508-
dc.description.abstractReal-time quantitative and qualitative analyses of metastasis-associated proteases are critical for precise diagnosis and novel therapeutic treatment of advanced cancers. However, conventional methods based on DNA, peptides, and proteins require sophisticated chemistry and additional processes to expose detection moieties, and they lack elements of temporal control, which limit their applicability. We designed unique protease-activatable polymersomes (PeptiSomes) for high sensitivity, in situ quantitative analysis of activating membrane-type 1 matrix metalloproteinases (MT1-MMP, MMP14). To do this, we first synthesized an amphiphilic block polymer–peptide and a copolypeptide based on mPEG-b-pLeu and MT1-peptide-b-pLeu, respectively. Amphiphilic self-assembled PeptiSomes in water were capable of disassembling and releasing the encapsulated self-quenched fluorescence dye (calcein) via enzymatic activation by MT1-MMP. Our PeptiSome system may potentially prevent the initiation and progression of cancer metastasis. Furthermore, the PeptiSome approach described here is likely to facilitate the development of rapid protease assay techniques and further extend the role of proteases as metastasis indicators and therapeutic targets.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherRoyal Society of Chemistry Pub.-
dc.relation.isPartOfJournal of Materials Chemistry B-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAnchored protease-activatable polymersomes for molecular diagnostics of metastatic cancer cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorHyun-Ouk Kim-
dc.contributor.googleauthorJong-Woo Lim-
dc.contributor.googleauthorJihye Choi-
dc.contributor.googleauthorHwunjae Lee-
dc.contributor.googleauthorHye Young Son-
dc.contributor.googleauthorJihye Kim-
dc.contributor.googleauthorGeunseon Park-
dc.contributor.googleauthorHaejin Chun-
dc.contributor.googleauthorDaesub Song-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSeungjoo Haam-
dc.identifier.doi10.1039/C7TB01675A-
dc.contributor.localIdA04589-
dc.contributor.localIdA05431-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ01573-
dc.identifier.eissn2050-7518-
dc.identifier.urlhttp://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb01675a#!divAbstract-
dc.contributor.alternativeNameSon, Hye Yeong-
dc.contributor.alternativeNameChoi, Jihye-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorSon, Hye Yeong-
dc.contributor.affiliatedAuthorChoi, Jihye-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.citation.volume5-
dc.citation.number48-
dc.citation.startPage9571-
dc.citation.endPage9578-
dc.identifier.bibliographicCitationJournal of Materials Chemistry B, Vol.5(48) : 9571-9578, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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