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Combination Therapy with Capecitabine and Cisplatin as Second-Line Chemotherapy for Advanced Biliary Tract Cancer

Authors
 Jung J.H.  ;  Lee H.S.  ;  Jo J.H.  ;  Cho I.R.  ;  Chung M.J.  ;  Bang S.  ;  Park S.W.  ;  · Song S.Y.  ;  Park J.Y. 
Citation
 Chemotherapy, Vol.62(6) : 361-366, 2017 
Journal Title
 Chemotherapy 
ISSN
 0009-3157 
Issue Date
2017
Keywords
Biliary tract neoplasm ; Capecitabine ; Cisplatin ; Drug therapy ; Palliative care
Abstract
BACKGROUND/AIMS: Palliative chemotherapy is the main treatment for advanced biliary tract cancer (BTC). However, there is a lack of established second-line chemotherapy to treat disease progression after first-line chemotherapy. We examined combination therapy with capecitabine and cisplatin for advanced BTC as a second-line regimen. METHODS: We analyzed the medical records of 40 patients diagnosed with BTC who received palliative second-line chemotherapy with capecitabine and cisplatin. RESULTS: The median overall survival from the start of second-line chemotherapy was 6.3 months. The median overall survival from diagnosis was 17.9 months. The median progression-free survival during second-line chemotherapy was 2.3 months. Nine (30%) patients experienced adverse events of grade ≥3. Eastern Cooperative Oncology Group performance score was an independent predictor of adverse events. CONCLUSIONS: Combination therapy with capecitabine and cisplatin may be an option for second-line chemotherapy in some of patients with advanced BTC.
Full Text
https://www.karger.com/Article/Abstract/479425
DOI
10.1159/000479425
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
박승우(Park, Seung Woo) ORCID logo https://orcid.org/0000-0001-8230-964X
박정엽(Park, Jeong Youp) ORCID logo https://orcid.org/0000-0003-0110-8606
방승민(Bang, Seungmin) ORCID logo https://orcid.org/0000-0001-5209-8351
송시영(Song, Si Young) ORCID logo https://orcid.org/0000-0002-1417-4314
이희승(Lee, Hee Seung)
정문재(Chung, Moon Jae) ORCID logo https://orcid.org/0000-0002-5920-8549
정장한(Jung, Jang Han)
조인래(Cho, In Rae)
조중현(Jo, Jung Hyun) ORCID logo https://orcid.org/0000-0002-2641-8873
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161497
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