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Brain metabolism in patients with freezing of gait after hypoxic-ischemic brain injury: A pilot study

Authors
 Seo Yeon Yoon  ;  Sang Chul Lee  ;  Na Young Kim  ;  Young-Sil An  ;  Yong Wook Kim 
Citation
 MEDICINE, Vol.96(45) : e8212, 2017 
Journal Title
MEDICINE
ISSN
 0025-7974 
Issue Date
2017
MeSH
Adult ; Aged ; Brain/metabolism ; Brain Ischemia/complications ; Cerebral Cortex/metabolism ; Female ; Fluorodeoxyglucose F18 ; Gait Disorders, Neurologic/diagnostic imaging ; Gait Disorders, Neurologic/etiology ; Gait Disorders, Neurologic/physiopathology ; Glucose/metabolism ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Pilot Projects ; Positron-Emission Tomography ; Young Adult
Abstract
Movement disorders are 1 of the long-term neurological complications that can occur after hypoxic-ischemic brain injury (HIBI). However, freezing of gait (FOG) after HIBI is rare. The aim of this study was to examine the brain metabolism of patients with FOG after HIBI using F-18 fluoro-2-deoxy-D-glucose positron emission tomography (F-18 FDG PET).We consecutively enrolled 11 patients with FOG after HIBI. The patients' overall brain metabolism was measured by F-18 FDG PET, and we compared their regional brain metabolic activity with that from 15 healthy controls using a voxel-by-voxel-based statistical mapping analysis. Additionally, we correlated each patient's FOG severity with the brain metabolism using a covariance analysis.Patients with FOG had significantly decreased brain glucose metabolism in the midbrain, bilateral thalamus, bilateral cingulate gyri, right supramarginal gyrus, right angular gyrus, right paracentral lobule, and left precentral gyrus (PFDR-corrected < .01, k = 50). No significant increases in brain metabolism were noted in patients with FOG. The covariance analysis identified significant correlations between the FOG severity and the brain metabolism in the right lingual gyrus, left fusiform gyrus, and bilateral cerebellar crus I (Puncorrected < 0.001, k = 50).Our data suggest that brain regions in the gait-related neural network, including the cerebral cortex, subcortical structures, brainstem, and cerebellum, may significantly contribute to the development of FOG in HIBI. Moreover, the FOG severity may be associated with the visual cortex and cerebellar regions.
Files in This Item:
T201704816.pdf Download
DOI
10.1097/MD.0000000000008212
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Na Young(김나영) ORCID logo https://orcid.org/0000-0001-9888-3953
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Yoon, Seo Yeon(윤서연)
Lee, Sang Chul(이상철) ORCID logo https://orcid.org/0000-0002-6241-7392
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161444
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