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Clinical Parameter for Deciding the BRAFV600E Mutation Test in Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Thyroid Nodules: US Features According to TIRADS.

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dc.contributor.author곽진영-
dc.contributor.author김은경-
dc.contributor.author노미리비-
dc.contributor.author문희정-
dc.contributor.author박영진-
dc.contributor.author윤정현-
dc.date.accessioned2018-07-20T11:52:49Z-
dc.date.available2018-07-20T11:52:49Z-
dc.date.issued2017-
dc.identifier.issn0894-8771-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161443-
dc.description.abstractThis study aimed to investigate the usefulness of a thyroid imaging reporting and data system (TIRADS) to select thyroid nodules with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) cytology for additional BRAF mutation testing. Three hundred three thyroid nodules were included. Statistical analysis was performed at both patient and nodule levels according to BRAF mutation positivity and clinical factors. Univariate and multivariate logistic regression analyses were performed to assess independent associations between BRAF mutation positivity and clinical factors. Of 303 AUS/FLUS nodules, 16 (5.3%) of 303 nodules had the BRAF mutation. The frequency of the BRAF mutation according to the TIRADS was 35.7% for category 5, 10.8% for category 4c, 2.5% for category 4b, 1.1% for category 4a, and 0% for category 3 nodules (P < 0.001). On multivariate analysis, BRAF mutation positivity was significantly associated with high suspicion on the TIRADS (odds ratio, 15.247; P < 0.001). In conclusion, the ultrasonography patterns of the TIRADS can be used as a clinical parameter for deciding the BRAF mutation test in thyroid nodules with AUS/FLUS cytology.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfULTRASOUND QUARTERLY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical Parameter for Deciding the BRAFV600E Mutation Test in Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Thyroid Nodules: US Features According to TIRADS.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorMiribi Rho-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorVivian Y. Park-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorJin Young Kwak-
dc.identifier.doi10.1097/RUQ.0000000000000313-
dc.contributor.localIdA00182-
dc.contributor.localIdA00801-
dc.contributor.localIdA05327-
dc.contributor.localIdA01397-
dc.contributor.localIdA01572-
dc.contributor.localIdA02595-
dc.relation.journalcodeJ02771-
dc.identifier.eissn1536-0253-
dc.identifier.pmid28877096-
dc.identifier.urlhttps://oce.ovid.com/article/00013644-201712000-00007/HTML-
dc.contributor.alternativeNameKwak, Jin Young-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameRho, Miribi-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNamePark, Vivian Young Jean-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.affiliatedAuthorKwak, Jin Young-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorRho, Miribi-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorPark, Vivian Youngjean-
dc.contributor.affiliatedAuthorYoon, Jung Hyun-
dc.citation.volume33-
dc.citation.number4-
dc.citation.startPage284-
dc.citation.endPage288-
dc.identifier.bibliographicCitationULTRASOUND QUARTERLY, Vol.33(4) : 284-288, 2017-
dc.identifier.rimsid61352-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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