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Population pharmacokinetics of remifentanil in critically ill patients receiving extracorporeal membrane oxygenation

 Seungwon Yang  ;  Hayeon Noh  ;  Jongsung Hahn  ;  Byung Hak Jin  ;  Kyoung Lok Min  ;  Soo Kyung Bae  ;  Jiseon Kim  ;  Min Soo Park  ;  Taegon Hong  ;  Jin Wi  ;  Min Jung Chang 
 SCIENTIFIC REPORTS, Vol.7(1) : 16276, 2017 
Journal Title
Issue Date
Extracorporeal membrane oxygenation (ECMO) is associated with pharmacokinetic (PK) changes of drugs. It presents considerable challenges to providing optimal dosing regimens for patients receiving ECMO. We aimed to describe the population PK of remifentanil in critically ill adult patients receiving venoartrial extracorporeal membrane oxygenation (VA-ECMO) and to identify determinants associated with altered remifentanil concentrations. The population PK model of remifentanil was developed using nonlinear mixed effects modelling (NONMEM). Fifteen adult patients who received a continuous infusion of remifentanil during VA-ECMO participated in the study. The PK of remifentanil was best described by a one-compartment model with additive and proportional residual errors. Remifentanil concentrations were affected by sex and ECMO pump speed. The final PK model included the effect of sex and ECMO pump speed on clearance is developed as followed: clearance (L/h) = 366 × 0.502sex × (ECMO pump speed/2350)2.04 and volume (L) = 41. Remifentanil volume and clearance were increased in adult patients on VA-ECMO compared with previously reported patients not on ECMO. We suggest that clinicians should consider an increased remifentanil dosing to achieve the desired level of sedation and provide a dosing regimen according to sex and ECMO pump speed.
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6. Others (기타) > Dept. of Clinical Pharmacology (임상시험센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Wi, Jin(위진) ORCID logo https://orcid.org/0000-0003-0655-5130
Hong, Tae Gon(홍태곤) ORCID logo https://orcid.org/0000-0001-7490-0085
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