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Prevalence of depression and suicidal ideation increases proportionally with renal function decline, beginning from early stages of chronic kidney disease.

 Jong H. Jhee  ;  Eun Lee  ;  Min-Uk Cha  ;  Misol Lee  ;  Hyoungnae Kim  ;  Seohyun Park  ;  Hae-Ryong Yun  ;  Su-Young Jung  ;  Youn K. Kee  ;  Chang-Yun Yoon  ;  Seung H. Han  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Jung T. Park 
 Medicine, Vol.96(44) : e8476, 2017 
Journal Title
Issue Date
Adult ; Depression/epidemiology ; Depression/etiology ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Odds Ratio ; Prevalence ; Prospective Studies ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/psychology ; Republic of Korea/epidemiology ; Risk Factors ; Suicidal Ideation ; Time Factors
Depression and suicidal ideation are prevalent mental health problems in patients with chronic kidney disease (CKD. However, the association between mental health problems and kidney disease has been investigated in severe cases only. Thus, this study evaluated the relationship between mental health problems and renal function in a community-based prospective cohort study comprising patients with mild to moderate kidney disease. A total of 44,938 participants who were participated in Korean National Health and Nutrition Examination Survey IV, V, and VI from 2007 to 2014 were enrolled. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. The study outcome was the prevalence of depression and suicidal ideations assessed by self-reporting surveys. Logistic regression analysis was performed to evaluate the relationship between renal function and outcomes. The mean age of the study subjects was 49.2 ± 16.6 years, and the mean eGFR was 94.0 mL/min/1.73 m. The prevalence of depression and suicidal ideation increased with decreasing eGFR. Multivariate logistic regression analysis showed that the risk of depression increased in subjects with eGFR <45 mL/min/1.73 m [odds ratio (OR) 1.47; 95% confidence interval (CI) 1.09-1.98]. The risk of suicidal ideation gradually increased in groups with eGFR <90 mL/min/1.73 m (OR, 1.11; 95% CI, 1.03-1.20), even after adjustments for confounding variables. In conclusion, depression and suicidal ideation are related closely with renal dysfunction. The risk of having depression and suicidal ideation increased even in patient with mild renal dysfunction. Therefore, evaluation and management strategies regarding mental health problems should be taken into account throughout all stages of CKD.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
강신욱(Kang, Shin Wook) ; 기연경(Kee, Youn Kyung) ; 김형래(Kim, Hyoung Rae) ; 박서현(Park, Seo Hyun) ; 박정탁(Park, Jung Tak) ; 유태현(Yoo, Tae Hyun) ; 윤창연(Yoon, Chang Yun) ; 윤해룡(Yun, Hae Ryong) ; 이미솔(Lee, Mi Sol) ; 이은(Lee, Eun) ; 정수영(Jung, Su Young) ; 지종현(Jhee, Jong Hyun) ; 차민욱(Cha, Min Uk) ; 한승혁(Han, Seung Hyeok)
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