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Decreased blood pressure associated with in-vehicle exposure to carbon monoxide in Korean volunteers

Authors
 Geon-Woo Lee  ;  Mun-Joo Bae  ;  Ji-Yeon Yang  ;  Jung-Woo Son  ;  Jae-Lim Cho  ;  Sang-Gyu Lee  ;  Bo-Mi Jang  ;  Hyun-Woo Lee  ;  Jong-Soon Lim  ;  Dong-Chun Shin  ;  Young-Wook Lim 
Citation
 Environmental Health and Preventive Medicine, Vol.22(1) : 34, 2017 
Journal Title
 Environmental Health and Preventive Medicine 
Issue Date
2017
MeSH
Adult ; Analysis of Variance ; Blood Pressure/drug effects* ; Carbon Monoxide/administration & dosage ; Carbon Monoxide/adverse effects* ; Carbon Monoxide/analysis ; Carboxyhemoglobin/analysis* ; Cognition ; Echocardiography ; Environmental Monitoring ; Female ; Humans ; Hypotension/chemically induced ; Male ; Middle Aged ; Republic of Korea ; Vehicle Emissions/toxicity ; Volunteers
Keywords
Blood pressure ; Carbon monoxide ; Carboxyhemoglobin ; Fatigue ; In-vehicle
Abstract
BACKGROUND: Carbon monoxide (CO) is one of the primary components of emissions from light-duty vehicles, and reportedly comprises 77% of all pollutants emitted in terms of concentration. Exposure to CO aggravates cardiovascular disease and causes other health disorders. The study was aimed to assess the negative effects by injecting different amounts of CO concentration directly to human volunteers boarding in the car. METHODS: Human volunteers were exposed to CO concentrations of 0, 33.2, and 72.4 ppm, respectively during the first test and 0, 30.3, and 48.8 ppm respectively during the second test while seated in the car. The volunteers were exposed to each concentration for approximately 45 min. After exposure, blood pressure measurement, blood collection (carboxyhemoglobin [COHb] analysis), medical interview, echocardiography test, and cognitive reaction test were performed. RESULT: In patients who were exposed to a mean concentration of CO for 72.4 ± 1.4 ppm during the first exposure test and 48.8 ± 3.7 ppm during the second exposure test, the COHb level exceeded 2%. Moreover, the diastolic blood pressure was decreased while increasing in CO concentration after exposure. The medical interview findings showed that the degree of fatigue was increased and the degree of concentration was reduced when the exposed concentration of CO was increased. CONCLUSION: Although the study had a limited sample size, we found that even a low concentration of CO flowing into a car could have a negative influence on human health, such as change of blood pressure and degree of fatigue.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161378
DOI
10.1186/s12199-017-0622-y
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute for Environmental Research (환경공해연구소)
Yonsei Authors
손정우(Sohn, Jung Woo) ; 신동천(Shin, Dong Chun) ; 양지연(Yang, Ji Yeon) ; 임영욱(Lim, Young Wook)
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