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The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter.

Authors
 Hye Won Lee  ;  Kwang Joon Kim  ;  Kyu Sik Jung  ;  Young Eun Chon  ;  Ji Hye Huh  ;  Kyeong Hye Park  ;  Jae Bock Chung  ;  Chang Oh Kim  ;  Kwang-Hyub Han  ;  Jun Yong Park 
Citation
 PLoS One, Vol.12(10) : e0187066, 2017 
Journal Title
 PLoS One 
Issue Date
2017
MeSH
Aged ; Fatty Liver/complications* ; Female ; Humans ; Male ; Middle Aged ; Obesity, Abdominal/complications*
Abstract
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. METHODS: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. RESULTS: Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001-1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001-1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P<0.001; 95% CI, 2.912-8.039) for 100<VFA≤200 cm2 and 7.474 (P<0.001; 95% CI, 2.462-22.693) for VFA >200 cm2, compared to patients with a VFA ≤100 cm2. CONCLUSIONS: Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161358
DOI
10.1371/journal.pone.0187066
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김광준(Kim, Kwang Joon) ; 김창오(Kim, Chang Oh) ; 박준용(Park, Jun Yong) ; 이혜원(Lee, Hye Won) ; 정규식(Jung, Kyu Sik) ; 정재복(Chung, Jae Bock) ; 한광협(Han, Kwang Hyup)
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