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The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter.

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dc.contributor.author김광준-
dc.contributor.author김창오-
dc.contributor.author박준용-
dc.contributor.author이혜원-
dc.contributor.author정규식-
dc.contributor.author정재복-
dc.contributor.author한광협-
dc.date.accessioned2018-07-20T08:41:04Z-
dc.date.available2018-07-20T08:41:04Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161358-
dc.description.abstractBACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. METHODS: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. RESULTS: Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001-1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001-1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P<0.001; 95% CI, 2.912-8.039) for 100<VFA≤200 cm2 and 7.474 (P<0.001; 95% CI, 2.462-22.693) for VFA >200 cm2, compared to patients with a VFA ≤100 cm2. CONCLUSIONS: Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHFatty Liver/complications*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObesity, Abdominal/complications*-
dc.titleThe relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorKyu Sik Jung-
dc.contributor.googleauthorYoung Eun Chon-
dc.contributor.googleauthorJi Hye Huh-
dc.contributor.googleauthorKyeong Hye Park-
dc.contributor.googleauthorJae Bock Chung-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorJun Yong Park-
dc.identifier.doi10.1371/journal.pone.0187066-
dc.contributor.localIdA00317-
dc.contributor.localIdA01044-
dc.contributor.localIdA01675-
dc.contributor.localIdA03318-
dc.contributor.localIdA03578-
dc.contributor.localIdA03706-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid29077769-
dc.contributor.alternativeNameKim, Kwang Joon-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameLee, Hye Won-
dc.contributor.alternativeNameJung, Kyu Sik-
dc.contributor.alternativeNameChung, Jae Bock-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorLee, Hye Won-
dc.contributor.affiliatedAuthorJung, Kyu Sik-
dc.contributor.affiliatedAuthorChung, Jae Bock-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.citation.volume12-
dc.citation.number10-
dc.citation.startPagee0187066-
dc.identifier.bibliographicCitationPLOS ONE, Vol.12(10) : e0187066, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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