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Alterations in Gut Microbiota and Immunity by Dietary Fat.

Authors
 Bo-Gie Yang  ;  Kyu Yeon Hur  ;  Myung-Shik Lee 
Citation
 Yonsei Medical Journal, Vol.58(6) : 1083-1091, 2017 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2017
MeSH
Diet, High-Fat* ; Dietary Fats ; Gastrointestinal Microbiome* ; Humans ; Inflammatory Bowel Diseases ; Intestines ; Metabolic Syndrome* ; Obesity/physiopathology*
Keywords
Gut microbiota ; diabetes ; gut immunity ; obesity
Abstract
Gut microbiota play critical physiological roles in energy extraction from the intestine and in the control of systemic immunity, as well as local intestinal immunity. Disturbance of gut microbiota leads to the development of several diseases, such as colitis, inflammatory bowel diseases, metabolic disorders, cancer, etc. From a metabolic point of view, the gut is a large metabolic organ and one of the first to come into contact with dietary fats. Interestingly, excessive dietary fat has been incriminated as a primary culprit of metabolic syndrome and obesity. After intake of high-fat diet or Western diet, extensive changes in gut microbiota have been observed, which may be an underlying cause of alterations in whole body metabolism and nutrient homeostasis. Here, we summarize recent data on changes in the gut microbiota and immunity associated with dietary fat, as well as their relationships with the pathogenesis of metabolic syndrome. These findings may provide insight into the understanding of the complex pathophysiology related to the development of metabolic diseases and offer an opportunity to develop novel candidates for therapeutic agents.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161308
DOI
10.3349/ymj.2017.58.6.1083
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
이명식(Lee, Myung Shik)
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