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Effect of yttrium-90 radioembolization on outcomes in Asian patients with early to advanced stage hepatocellular carcinoma

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dc.contributor.author김도영-
dc.contributor.author원종윤-
dc.contributor.author한광협-
dc.date.accessioned2018-07-20T08:34:54Z-
dc.date.available2018-07-20T08:34:54Z-
dc.date.issued2017-
dc.identifier.issn1386-6346-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161300-
dc.description.abstractAIM: The aim of this study was to investigate the effect of yttrium-90 radioembolization on the outcome of Asian patients with early to advanced stage hepatocellular carcinoma (HCC). METHODS: Sixty-two patients were screened and 50 patients (80.6%) were eligible. Response was evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST), and overall survival was estimated using the Kaplan-Meier method. RESULTS: The Barcelona Clinic Liver Cancer (BCLC) stage was A in 40% of patients, B in 24%, and C in 36%; 66% of patients had hepatitis B virus infections. According to RECIST criteria, partial responses occurred in 40% of patients, and stable disease was achieved in 46%. Tumor response was significantly associated with BCLC stage (P = 0.003). The median overall time to progression was 5.8 months (range, 0.9-46.1 months). Follow-up treatments after radioembolization were carried out in 31 patients due to remnant HCC (n = 18) or HCC progression (n = 13). The median overall survival was 40.9 months (95% confidence interval, 10.2-71.6 months). Treatment was tolerable except for one lung toxicity and two hepatic toxicities. CONCLUSION: Yttrium-90 radioembolization appears to be well tolerated and effective in Asian patients with BCLC stage A-C HCC. Follow-up treatments after radioembolization can be safely provided.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Publishing-
dc.relation.isPartOfHEPATOLOGY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffect of yttrium-90 radioembolization on outcomes in Asian patients with early to advanced stage hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHyun Young Woo-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorJeong Heo-
dc.contributor.googleauthorChang Won Kim-
dc.contributor.googleauthorSuk Kim-
dc.contributor.googleauthorKi Tae Yoon-
dc.contributor.googleauthorWon Lim-
dc.contributor.googleauthorYoung Mi Hong-
dc.contributor.googleauthorJong Yun Won-
dc.contributor.googleauthorSangheun Lee-
dc.contributor.googleauthorKwang Hyub Han-
dc.contributor.googleauthorMong Cho-
dc.identifier.doi10.1111/hepr.12759-
dc.contributor.localIdA00385-
dc.contributor.localIdA02443-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ00987-
dc.identifier.eissn1872-034X-
dc.identifier.pmid27272116-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/hepr.12759-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordradioembolization-
dc.subject.keywordyttrium-90-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameWon, Jong Yun-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.contributor.affiliatedAuthorWon, Jong Yun-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.citation.volume47-
dc.citation.number5-
dc.citation.startPage387-
dc.citation.endPage397-
dc.identifier.bibliographicCitationHEPATOLOGY RESEARCH, Vol.47(5) : 387-397, 2017-
dc.identifier.rimsid61222-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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