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Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review

Authors
 Keum Hwa Lee  ;  Andreas Kronbichler  ;  David Duck-Young Park  ;  YoungMin Park  ;  Hanwool Moon  ;  Hyungdo Kim  ;  Jun Hyug Choi  ;  YoungSeo Choi  ;  Songjoo Shim  ;  Il Suk Lyu  ;  Byung Hwan Yun  ;  Yeonseung Han  ;  Donghee Lee  ;  Sang Yoon Lee  ;  Byung Hun Yoo  ;  Kyung Hwan Lee  ;  Tai Lim Kim  ;  Heonki Kim  ;  Joo Sung Shim  ;  Wonseok Nam  ;  Heesung So  ;  SooYeon Choi  ;  Sangmok Lee  ;  Jae Il Shin 
Citation
 Autoimmunity Reviews, Vol.16(11) : 1160-1173, 2017 
Journal Title
 Autoimmunity Reviews 
ISSN
 1568-9972 
Issue Date
2017
MeSH
Autoimmune Diseases/immunology* ; Autoimmunity/immunology* ; Extracellular Traps/immunology* ; Humans ; Neutrophils/immunology* ; Prognosis
Keywords
ANCA-associated vasculitis (AAV) ; Anti-neutrophil cytoplasmic antibodies (ANCA) ; Autoimmunity ; Interleukin-8 (IL-8) ; Neutrophil extracellular traps (NETs) ; Neutrophils ; Rheumatoid arthritis (RA) ; Systemic lupus erythematosus (SLE)
Abstract
Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between "NETosis," which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Neutrophils, interleukin-8, ANCA and other inflammatory molecules are considered to play a key role in NET formation. Prolonged exposure to NETs-related cascades is associated with autoimmunity and increases the chance of systemic organ damage. In this review, we discuss the roles of various inflammatory molecules in relation to NETs. We also describe the role of NETs in the pathogenesis of autoimmune diseases and discuss the possibility of using targeted therapies directed to NETs and associated molecules to treat autoimmune diseases.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161288
DOI
10.1016/j.autrev.2017.09.012
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
신재일(Shin, Jae Il) ; 이금화(Lee, Geum Hwa)
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Full Text
https://www.sciencedirect.com/science/article/pii/S1568997217302367
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