0 360

Cited 99 times in

Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review

DC Field Value Language
dc.contributor.author신재일-
dc.contributor.author이금화-
dc.date.accessioned2018-07-20T08:33:58Z-
dc.date.available2018-07-20T08:33:58Z-
dc.date.issued2017-
dc.identifier.issn1568-9972-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161288-
dc.description.abstractNeutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between "NETosis," which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Neutrophils, interleukin-8, ANCA and other inflammatory molecules are considered to play a key role in NET formation. Prolonged exposure to NETs-related cascades is associated with autoimmunity and increases the chance of systemic organ damage. In this review, we discuss the roles of various inflammatory molecules in relation to NETs. We also describe the role of NETs in the pathogenesis of autoimmune diseases and discuss the possibility of using targeted therapies directed to NETs and associated molecules to treat autoimmune diseases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfAUTOIMMUNITY REVIEWS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAutoimmune Diseases/immunology*-
dc.subject.MESHAutoimmunity/immunology*-
dc.subject.MESHExtracellular Traps/immunology*-
dc.subject.MESHHumans-
dc.subject.MESHNeutrophils/immunology*-
dc.subject.MESHPrognosis-
dc.titleNeutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorKeum Hwa Lee-
dc.contributor.googleauthorAndreas Kronbichler-
dc.contributor.googleauthorDavid Duck-Young Park-
dc.contributor.googleauthorYoungMin Park-
dc.contributor.googleauthorHanwool Moon-
dc.contributor.googleauthorHyungdo Kim-
dc.contributor.googleauthorJun Hyug Choi-
dc.contributor.googleauthorYoungSeo Choi-
dc.contributor.googleauthorSongjoo Shim-
dc.contributor.googleauthorIl Suk Lyu-
dc.contributor.googleauthorByung Hwan Yun-
dc.contributor.googleauthorYeonseung Han-
dc.contributor.googleauthorDonghee Lee-
dc.contributor.googleauthorSang Yoon Lee-
dc.contributor.googleauthorByung Hun Yoo-
dc.contributor.googleauthorKyung Hwan Lee-
dc.contributor.googleauthorTai Lim Kim-
dc.contributor.googleauthorHeonki Kim-
dc.contributor.googleauthorJoo Sung Shim-
dc.contributor.googleauthorWonseok Nam-
dc.contributor.googleauthorHeesung So-
dc.contributor.googleauthorSooYeon Choi-
dc.contributor.googleauthorSangmok Lee-
dc.contributor.googleauthorJae Il Shin-
dc.identifier.doi10.1016/j.autrev.2017.09.012-
dc.contributor.localIdA02142-
dc.contributor.localIdA04622-
dc.relation.journalcodeJ03068-
dc.identifier.eissn1873-0183-
dc.identifier.pmid28899799-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1568997217302367-
dc.subject.keywordANCA-associated vasculitis (AAV)-
dc.subject.keywordAnti-neutrophil cytoplasmic antibodies (ANCA)-
dc.subject.keywordAutoimmunity-
dc.subject.keywordInterleukin-8 (IL-8)-
dc.subject.keywordNeutrophil extracellular traps (NETs)-
dc.subject.keywordNeutrophils-
dc.subject.keywordRheumatoid arthritis (RA)-
dc.subject.keywordSystemic lupus erythematosus (SLE)-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.alternativeNameLee, Geum Hwa-
dc.contributor.affiliatedAuthorShin, Jae Il-
dc.contributor.affiliatedAuthorLee, Geum Hwa-
dc.citation.volume16-
dc.citation.number11-
dc.citation.startPage1160-
dc.citation.endPage1173-
dc.identifier.bibliographicCitationAUTOIMMUNITY REVIEWS, Vol.16(11) : 1160-1173, 2017-
dc.identifier.rimsid61210-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.