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Predictive Factors of Unfavorable Events After Gamma Knife Radiosurgery for Vestibular Schwannoma.

Authors
 Ji Hee Kim  ;  Hyun Ho Jung  ;  Jong Hee Chang  ;  Jin Woo Chang  ;  Yong Gou Park  ;  Won Seok Chang 
Citation
 World Neurosurgery, Vol.107 : 175-184, 2017 
Journal Title
 World Neurosurgery 
ISSN
 1878-8750 
Issue Date
2017
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Disease Progression ; Facial Nerve Diseases/etiology ; Facial Nerve Diseases/prevention & control ; Female ; Hearing Loss/etiology ; Hearing Loss/prevention & control ; Humans ; Hydrocephalus/etiology ; Male ; Middle Aged ; Myokymia/etiology ; Neuroma, Acoustic/radiotherapy* ; Organ Sparing Treatments/methods ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Radiosurgery/adverse effects* ; Retrospective Studies ; Risk Factors ; Trigeminal Nerve Diseases/etiology ; Vertigo/etiology ; Young Adult
Keywords
Complication ; Gamma Knife surgery ; Hearing preservation ; Hydrocephalus ; Predictive factor ; Pseudoprogression ; Vestibular schwannoma
Abstract
OBJECTIVE: Gamma Knife radiosurgery (GKS) for the treatment of vestibular schwannoma (VS) introduces risks to the facial nerve and auditory perception and may involve post-treatment complications such as pseudoprogression, hydrocephalus, and other cranial neuropathies. This study of patients with VS who underwent GKS investigated radiosurgical results, focusing on post-treatment complications and identifying the factors that predict such complications. METHODS: We undertook a retrospective review of all VS patients treated with the Perfexion Leksell Gamma Knife between November 2007 and October 2010 at our institution. Patients who underwent at least 12 months of clinical and radiologic assessments before and after GKS were included. RESULTS: All 235 patients were included in the analyses reported here. The 5-year serviceable hearing and facial nerve preservation values were 73.9% and 94.3%, respectively. Following GKS, 43 patients (18.30%) showed pseudoprogression, 15 (6.38%) exhibited hydrocephalus, 22 (9.36%) showed trigeminal neuropathy, 14 (5.96%) showed vertigo, and 25 (10.64%) showed facial myokymia. According to multivariate analysis, solid tumor nature was significantly associated with pseudoprogression and patient age was significantly associated with hydrocephalus. Patients receiving margin doses ≥13 Gy had a significantly higher probability of loss of serviceable hearing. Patients with smaller tumors had a trigeminal nerve preservation rate comparable with patients harboring larger tumors. Patients receiving margin doses <13 Gy or older patients had a significantly higher probability of vestibular nerve dysfunction. CONCLUSIONS: Further prospective studies should be designed to provide further insight into the exact relationship between the predictive factors we investigated and post-treatment complications.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161266
DOI
10.1016/j.wneu.2017.07.139
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
박용구(Park, Yong Gou) ; 장원석(Chang, Won Seok) ; 장종희(Chang, Jong Hee) ; 장진우(Chang, Jin Woo) ; 정현호(Jung, Hyun Ho)
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Full Text
https://www.sciencedirect.com/science/article/pii/S1878875017312391
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