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Predictive Factors of Unfavorable Events After Gamma Knife Radiosurgery for Vestibular Schwannoma.

DC Field Value Language
dc.contributor.author박용구-
dc.contributor.author장원석-
dc.contributor.author장종희-
dc.contributor.author장진우-
dc.contributor.author정현호-
dc.date.accessioned2018-07-20T08:31:37Z-
dc.date.available2018-07-20T08:31:37Z-
dc.date.issued2017-
dc.identifier.issn1878-8750-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161266-
dc.description.abstractOBJECTIVE: Gamma Knife radiosurgery (GKS) for the treatment of vestibular schwannoma (VS) introduces risks to the facial nerve and auditory perception and may involve post-treatment complications such as pseudoprogression, hydrocephalus, and other cranial neuropathies. This study of patients with VS who underwent GKS investigated radiosurgical results, focusing on post-treatment complications and identifying the factors that predict such complications. METHODS: We undertook a retrospective review of all VS patients treated with the Perfexion Leksell Gamma Knife between November 2007 and October 2010 at our institution. Patients who underwent at least 12 months of clinical and radiologic assessments before and after GKS were included. RESULTS: All 235 patients were included in the analyses reported here. The 5-year serviceable hearing and facial nerve preservation values were 73.9% and 94.3%, respectively. Following GKS, 43 patients (18.30%) showed pseudoprogression, 15 (6.38%) exhibited hydrocephalus, 22 (9.36%) showed trigeminal neuropathy, 14 (5.96%) showed vertigo, and 25 (10.64%) showed facial myokymia. According to multivariate analysis, solid tumor nature was significantly associated with pseudoprogression and patient age was significantly associated with hydrocephalus. Patients receiving margin doses ≥13 Gy had a significantly higher probability of loss of serviceable hearing. Patients with smaller tumors had a trigeminal nerve preservation rate comparable with patients harboring larger tumors. Patients receiving margin doses <13 Gy or older patients had a significantly higher probability of vestibular nerve dysfunction. CONCLUSIONS: Further prospective studies should be designed to provide further insight into the exact relationship between the predictive factors we investigated and post-treatment complications.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfWORLD NEUROSURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHDisease Progression-
dc.subject.MESHFacial Nerve Diseases/etiology-
dc.subject.MESHFacial Nerve Diseases/prevention & control-
dc.subject.MESHFemale-
dc.subject.MESHHearing Loss/etiology-
dc.subject.MESHHearing Loss/prevention & control-
dc.subject.MESHHumans-
dc.subject.MESHHydrocephalus/etiology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyokymia/etiology-
dc.subject.MESHNeuroma, Acoustic/radiotherapy*-
dc.subject.MESHOrgan Sparing Treatments/methods-
dc.subject.MESHPostoperative Complications/etiology-
dc.subject.MESHPostoperative Complications/prevention & control-
dc.subject.MESHRadiosurgery/adverse effects*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTrigeminal Nerve Diseases/etiology-
dc.subject.MESHVertigo/etiology-
dc.subject.MESHYoung Adult-
dc.titlePredictive Factors of Unfavorable Events After Gamma Knife Radiosurgery for Vestibular Schwannoma.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurosurgery-
dc.contributor.googleauthorJi Hee Kim-
dc.contributor.googleauthorHyun Ho Jung-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorJin Woo Chang-
dc.contributor.googleauthorYong Gou Park-
dc.contributor.googleauthorWon Seok Chang-
dc.identifier.doi10.1016/j.wneu.2017.07.139-
dc.contributor.localIdA01578-
dc.contributor.localIdA03454-
dc.contributor.localIdA03470-
dc.contributor.localIdA03484-
dc.contributor.localIdA03775-
dc.relation.journalcodeJ02806-
dc.identifier.eissn1878-8769-
dc.identifier.pmid28826715-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1878875017312391-
dc.subject.keywordComplication-
dc.subject.keywordGamma Knife surgery-
dc.subject.keywordHearing preservation-
dc.subject.keywordHydrocephalus-
dc.subject.keywordPredictive factor-
dc.subject.keywordPseudoprogression-
dc.subject.keywordVestibular schwannoma-
dc.contributor.alternativeNamePark, Yong Gou-
dc.contributor.alternativeNameChang, Won Seok-
dc.contributor.alternativeNameChang, Jong Hee-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.alternativeNameJung, Hyun Ho-
dc.contributor.affiliatedAuthorPark, Yong Gou-
dc.contributor.affiliatedAuthorChang, Won Seok-
dc.contributor.affiliatedAuthorChang, Jong Hee-
dc.contributor.affiliatedAuthorChang, Jin Woo-
dc.contributor.affiliatedAuthorJung, Hyun Ho-
dc.citation.volume107-
dc.citation.startPage175-
dc.citation.endPage184-
dc.identifier.bibliographicCitationWORLD NEUROSURGERY, Vol.107 : 175-184, 2017-
dc.identifier.rimsid61188-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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