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Alteration of Inflammatory Mediators in the Upper and Lower Airways under Chronic Intermittent Hypoxia: Preliminary Animal Study

Authors
 Eun Jung Lee  ;  Woon Heo  ;  Joo Young Kim  ;  Hyungchul Kim  ;  Min Jung Kang  ;  Bo Ra Kim  ;  Ji Hyun Kim  ;  Do Yang Park  ;  Chang-Hoon Kim  ;  Joo-Heon Yoon  ;  Hyung-Ju Cho 
Citation
 Mediators of Inflammation, Vol.2017 : 4327237, 2017 
Journal Title
 Mediators of Inflammation 
ISSN
 0962-9351 
Issue Date
2017
Abstract
PURPOSE: We hypothesized that CIH may affect the upper airway immune system and aimed to verify whether CIH can induce airway inflammation in a murine obstructive sleep apnea (OSA) model. METHODS: C57BL6 male mice were exposed to intermittent hypoxia (CIH group; 5 ~ 21% FiO2, 120 sec cycles, 12 h/d, n = 6) or room air (Sham group, n = 6) for up to 4 weeks in identical chambers. Nasal and lung tissues and lavage fluid were collected and analyzed by multiplex assay. Lung lavage fluid was also utilized for FACS analysis to determine eosinophil count. RESULTS: We determined the protein level of 24 different cytokines, chemokines, and inflammatory mediators. Among various cytokines, levels of IL-1α, IL-1β, IL-4, IL-6, and IL-13 were significantly elevated in nose or lung tissue from the CIH group. In addition, MCP-1 and periostin were elevated in nose and lung tissue and lavage fluid from the CIH group. CONCLUSIONS: CIH for 4 weeks altered the levels of inflammatory mediators in both the nose and lungs of mouse model. We suggest that the airway immune system may be deteriorated by CIH and allergic inflammation in the upper or lower airway could be worsened by sleep apnea.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161246
DOI
10.1155/2017/4327237
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실)
Yonsei Authors
김창훈(Kim, Chang Hoon)
윤주헌(Yoon, Joo Heon)
이은정(Lee, Eun Jung)
조형주(Cho, Hyung Ju)
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