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Treatment patterns and medication adherence of patients with glaucoma in South Korea

 Chan Yun Kim  ;  Ki Ho Park  ;  Jaehong Ahn  ;  Myung-Douk Ahn  ;  Soon Cheol Cha  ;  Ho Soong Kim  ;  Joon Mo Kim  ;  Moon Jung Kim  ;  Tae-Woo Kim  ;  Yong Yeon Kim  ;  Ji Woong Lee  ;  Sang-Woo Park  ;  Yong Ho Sohn  ;  Kyung Rim Sung  ;  Chungkwon Yoo  ;  Jinhye Cha  ;  Young-Joo Kim 
 BRITISH JOURNAL OF OPHTHALMOLOGY, Vol.101(6) : 801-807, 2017 
Journal Title
Issue Date
Aged ; Antihypertensive Agents/therapeutic use* ; Cross-Sectional Studies ; Drug Monitoring/methods ; Female ; Glaucoma/drug therapy* ; Glaucoma/epidemiology ; Glaucoma/physiopathology ; Humans ; Incidence ; Intraocular Pressure/drug effects* ; Male ; Medication Adherence/statistics & numerical data* ; Middle Aged ; Prospective Studies ; Republic of Korea/epidemiology ; Surveys and Questionnaires
Glaucoma ; Treatment Medical
BACKGROUND/AIMS: This study aimed to investigate treatment patterns and medication adherence of glaucoma. It also identified key factors associated with non-adherence.

METHODS: It was a cross-sectional, observational study. Patients who use eye-drops for ≤2 years were recruited at 15 eye clinics from March to November 2013. Data were collected through self-administered questionnaires and medical chart review. Medication adherence was evaluated using patients' self-report on pill count and defined as patients' administering drug for ≥80% of prescribed days. Medication adherence rate was calculated by dividing actual number of administration from total prescribed number of administration for 7 days. Patients whose self-reported prescription was different from total daily doses of physicians' prescription were considered as non-adherent.

RESULTS: A total of 1050 patients included, and medication adherence rate was evaluated in 1046 patients whose verification of adherence was available. Of the total, 27.4% were non-adherent, and the medication adherence rates of the total, the adherent, and the non-adherent were 90.6±17.8%, 96.8±5.5% and 56.6±24.7%, respectively. The most commonly used medication was prostaglandin (PGA) alone and the second was combination of two-class (β-blocker and carbonic anhydrase inhibitor (CAI)) and three-class combination of PGA, β-blocker and CAI followed. In multivariate analysis, the risk of non-adherence was 1.466 times greater in males than in females (95% CI 1.106 to 1.943) and 1.328-fold greater as the daily number of administration was increased (95% CI 1.186 to 1.487).

CONCLUSION: Approximately, one-third of the patients were non-adherent, and males and increased daily number of administration were associated with non-adherence. It highlights that more systematic treatment strategies should be considered for better medication adherence, leading to effective glaucoma management.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
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