10 15

Cited 2 times in

Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease.

Authors
 Gyuri Kim  ;  Kwang Joon Kim  ;  Yumie Rhee  ;  Sung-Kil Lim  ;  Salvatore Petta 
Citation
 PLoS One, Vol.12(7) : e0182202, 2017 
Journal Title
 PLoS One 
Issue Date
2017
MeSH
Aged ; Bone Density ; Bone Diseases, Metabolic/diagnostic imaging ; Bone Diseases, Metabolic/epidemiology ; Elasticity Imaging Techniques ; Female ; Femur/diagnostic imaging ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnostic imaging ; Lumbar Vertebrae/diagnostic imaging ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/pathology
Abstract
BACKGROUND: Metabolic bone disorders frequently occur in patients with chronic liver disease; however, the association between liver fibrosis and bone mineral density in patients with non-alcoholic fatty liver disease (NAFLD) is unclear. METHODS: This is a cross-sectional analysis of 231 asymptomatic subjects (160 women, 61.6 years old) from a university hospital setting, between February 2012 and December 2014. Bone mineral density (BMD) was measured at the lumbar spine, femur neck, and total hip using dual-energy X-ray absorptiometry (DXA). Liver fibrosis and steatosis were assessed using transient elastography. RESULTS: Among a total of 231 individuals, 129 subjects (55.8%) had NAFLD. BMDs at lumbar spine, femur neck, and total hip were significantly lower in patients having NAFLD with significant fibrosis, compared with patients having NAFLD without significant fibrosis (Ps<0.005). In patients with NAFLD, significant liver fibrosis revealed marked negative correlations with BMD at the lumber spine (r = -0.19, P = 0.032), femur neck (r = -0.19, P = 0.034), and total hip (r = -0.21, P = 0.016). A multivariate linear regression analysis revealed that significant liver fibrosis was independently correlated with low BMD at the femur neck (β = -0.18, P = 0.039) and total hip (β = -0.21, P = 0.005) after adjustment for age, sex, BMI, fasting plasma glucose, alanine aminotransferase, high-density lipoprotein cholesterol, and liver steatosis among patients with NAFLD. Using multivariable logistic regression, significant liver fibrosis was independently associated with overall osteopenia and osteoporosis in subjects having NAFLD (OR = 4.10, 95% CI = 1.02-16.45). CONCLUSION: The presence of significant liver fibrosis assessed via TE was independently associated with low BMD in NAFLD subjects.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161145
DOI
10.1371/journal.pone.0182202
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김광준(Kim, Kwang Joon)
김규리(Kim, Gyuri)
이유미(Rhee, Yumie)
임승길(Lim, Sung Kil)
사서에게 알리기
  feedback
Files in This Item:
T201704184.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse