Cited 22 times in
Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease.
DC Field | Value | Language |
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dc.contributor.author | 김광준 | - |
dc.contributor.author | 김규리 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 임승길 | - |
dc.date.accessioned | 2018-07-20T08:23:47Z | - |
dc.date.available | 2018-07-20T08:23:47Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161145 | - |
dc.description.abstract | BACKGROUND: Metabolic bone disorders frequently occur in patients with chronic liver disease; however, the association between liver fibrosis and bone mineral density in patients with non-alcoholic fatty liver disease (NAFLD) is unclear. METHODS: This is a cross-sectional analysis of 231 asymptomatic subjects (160 women, 61.6 years old) from a university hospital setting, between February 2012 and December 2014. Bone mineral density (BMD) was measured at the lumbar spine, femur neck, and total hip using dual-energy X-ray absorptiometry (DXA). Liver fibrosis and steatosis were assessed using transient elastography. RESULTS: Among a total of 231 individuals, 129 subjects (55.8%) had NAFLD. BMDs at lumbar spine, femur neck, and total hip were significantly lower in patients having NAFLD with significant fibrosis, compared with patients having NAFLD without significant fibrosis (Ps<0.005). In patients with NAFLD, significant liver fibrosis revealed marked negative correlations with BMD at the lumber spine (r = -0.19, P = 0.032), femur neck (r = -0.19, P = 0.034), and total hip (r = -0.21, P = 0.016). A multivariate linear regression analysis revealed that significant liver fibrosis was independently correlated with low BMD at the femur neck (β = -0.18, P = 0.039) and total hip (β = -0.21, P = 0.005) after adjustment for age, sex, BMI, fasting plasma glucose, alanine aminotransferase, high-density lipoprotein cholesterol, and liver steatosis among patients with NAFLD. Using multivariable logistic regression, significant liver fibrosis was independently associated with overall osteopenia and osteoporosis in subjects having NAFLD (OR = 4.10, 95% CI = 1.02-16.45). CONCLUSION: The presence of significant liver fibrosis assessed via TE was independently associated with low BMD in NAFLD subjects. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bone Density | - |
dc.subject.MESH | Bone Diseases, Metabolic/diagnostic imaging | - |
dc.subject.MESH | Bone Diseases, Metabolic/epidemiology | - |
dc.subject.MESH | Elasticity Imaging Techniques | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Femur/diagnostic imaging | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Cirrhosis/complications | - |
dc.subject.MESH | Liver Cirrhosis/diagnostic imaging | - |
dc.subject.MESH | Lumbar Vertebrae/diagnostic imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/complications | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/diagnostic imaging | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease/pathology | - |
dc.title | Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Gyuri Kim | - |
dc.contributor.googleauthor | Kwang Joon Kim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Sung-Kil Lim | - |
dc.contributor.googleauthor | Salvatore Petta | - |
dc.identifier.doi | 10.1371/journal.pone.0182202 | - |
dc.contributor.localId | A00317 | - |
dc.contributor.localId | A00322 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03375 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 28759632 | - |
dc.contributor.alternativeName | Kim, Kwang Joon | - |
dc.contributor.alternativeName | Kim, Gyuri | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Joon | - |
dc.contributor.affiliatedAuthor | Kim, Gyuri | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | e0182202 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.12(7) : e0182202, 2017 | - |
dc.identifier.rimsid | 61071 | - |
dc.type.rims | ART | - |
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