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Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease.

DC FieldValueLanguage
dc.contributor.author김광준-
dc.contributor.author김규리-
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.date.accessioned2018-07-20T08:23:47Z-
dc.date.available2018-07-20T08:23:47Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161145-
dc.description.abstractBACKGROUND: Metabolic bone disorders frequently occur in patients with chronic liver disease; however, the association between liver fibrosis and bone mineral density in patients with non-alcoholic fatty liver disease (NAFLD) is unclear. METHODS: This is a cross-sectional analysis of 231 asymptomatic subjects (160 women, 61.6 years old) from a university hospital setting, between February 2012 and December 2014. Bone mineral density (BMD) was measured at the lumbar spine, femur neck, and total hip using dual-energy X-ray absorptiometry (DXA). Liver fibrosis and steatosis were assessed using transient elastography. RESULTS: Among a total of 231 individuals, 129 subjects (55.8%) had NAFLD. BMDs at lumbar spine, femur neck, and total hip were significantly lower in patients having NAFLD with significant fibrosis, compared with patients having NAFLD without significant fibrosis (Ps<0.005). In patients with NAFLD, significant liver fibrosis revealed marked negative correlations with BMD at the lumber spine (r = -0.19, P = 0.032), femur neck (r = -0.19, P = 0.034), and total hip (r = -0.21, P = 0.016). A multivariate linear regression analysis revealed that significant liver fibrosis was independently correlated with low BMD at the femur neck (β = -0.18, P = 0.039) and total hip (β = -0.21, P = 0.005) after adjustment for age, sex, BMI, fasting plasma glucose, alanine aminotransferase, high-density lipoprotein cholesterol, and liver steatosis among patients with NAFLD. Using multivariable logistic regression, significant liver fibrosis was independently associated with overall osteopenia and osteoporosis in subjects having NAFLD (OR = 4.10, 95% CI = 1.02-16.45). CONCLUSION: The presence of significant liver fibrosis assessed via TE was independently associated with low BMD in NAFLD subjects.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBone Density-
dc.subject.MESHBone Diseases, Metabolic/diagnostic imaging-
dc.subject.MESHBone Diseases, Metabolic/epidemiology-
dc.subject.MESHElasticity Imaging Techniques-
dc.subject.MESHFemale-
dc.subject.MESHFemur/diagnostic imaging-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis/complications-
dc.subject.MESHLiver Cirrhosis/diagnostic imaging-
dc.subject.MESHLumbar Vertebrae/diagnostic imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/complications-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/diagnostic imaging-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/pathology-
dc.titleSignificant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorGyuri Kim-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorSung-Kil Lim-
dc.contributor.googleauthorSalvatore Petta-
dc.identifier.doi10.1371/journal.pone.0182202-
dc.contributor.localIdA00317-
dc.contributor.localIdA00322-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid28759632-
dc.contributor.alternativeNameKim, Kwang Joon-
dc.contributor.alternativeNameKim, Gyuri-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.contributor.affiliatedAuthorKim, Gyuri-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.citation.volume12-
dc.citation.number7-
dc.citation.startPagee0182202-
dc.identifier.bibliographicCitationPLOS ONE, Vol.12(7) : e0182202, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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