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The Protective Effect of Middle Cerebral Artery Calcification on Symptomatic Middle Cerebral Artery Infarction

DC FieldValueLanguage
dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author백장현-
dc.contributor.author송동범-
dc.contributor.author유준상-
dc.contributor.author허지회-
dc.date.accessioned2018-07-20T08:23:38Z-
dc.date.available2018-07-20T08:23:38Z-
dc.date.issued2017-
dc.identifier.issn0039-2499-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161144-
dc.description.abstractBACKGROUND AND PURPOSE: The presence of intracranial artery calcification is associated with an increased risk for stroke. However, calcified atherosclerotic plaques are also known to be less vulnerable to rupture. Given this discrepancy, we investigated whether the vulnerability of intracranial arterial atherosclerosis differed based on the presence or absence of calcification. METHODS: We considered consecutive patients with acute stroke in the unilateral middle cerebral artery (MCA) territory. Patients with any stenotic MCAs were included in this study. Symptomatic MCA was defined as the occurrence of infarctions relevant to the stenotic MCA. The presence of calcification in the MCA was evaluated on noncontrast thin-section computed tomography images using a 3dimensional software package. Generalized estimating equations were used to compare the frequency of calcification between symptomatic and asymptomatic stenosis. RESULTS: Of the 1066 MCAs examined in 533 patients, 645 MCAs were stenotic and were included in the study. Among the 645 stenotic MCAs, 406 MCAs (62.9%) were symptomatic. Calcification was observed in 36 MCAs (5.6%). Calcification in the MCA was more frequently observed in the asymptomatic group (7.9% versus 4.2%; P=0.032). On multivariable analysis, the presence of calcification in MCA atherosclerosis was less frequent in the symptomatic group (odds ratio, 0.46; 95% confidence interval, 0.23-0.92; P=0.027). CONCLUSIONS: This study showed that calcified atherosclerosis in the MCA was less frequently symptomatic.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfSTROKE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfarction, Middle Cerebral Artery*/epidemiology-
dc.subject.MESHInfarction, Middle Cerebral Artery*/pathology-
dc.subject.MESHInfarction, Middle Cerebral Artery*/physiopathology-
dc.subject.MESHIntracranial Arteriosclerosis*/epidemiology-
dc.subject.MESHIntracranial Arteriosclerosis*/pathology-
dc.subject.MESHIntracranial Arteriosclerosis*/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMiddle Cerebral Artery*/pathology-
dc.subject.MESHMiddle Cerebral Artery*/physiopathology-
dc.subject.MESHRegistries*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHVascular Calcification*/epidemiology-
dc.subject.MESHVascular Calcification*/pathology-
dc.subject.MESHVascular Calcification*/physiopathology-
dc.titleThe Protective Effect of Middle Cerebral Artery Calcification on Symptomatic Middle Cerebral Artery Infarction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorJang-Hyun Baek-
dc.contributor.googleauthorJoonsang Yoo-
dc.contributor.googleauthorDongbeom Song-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorJi Hoe Heo-
dc.identifier.doi10.1161/STROKEAHA.117.017821-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA01834-
dc.contributor.localIdA02017-
dc.contributor.localIdA02513-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02690-
dc.identifier.eissn1524-4628-
dc.identifier.pmid28939676-
dc.identifier.urlhttp://stroke.ahajournals.org/content/48/11/3138.long-
dc.subject.keywordatherosclerosis-
dc.subject.keywordintracranial stenosis-
dc.subject.keywordstroke-
dc.subject.keywordvascular calcification-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNameBaek, Jang Hyun-
dc.contributor.alternativeNameSong, Dong Beom-
dc.contributor.alternativeNameYoo, Joon Sang-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.affiliatedAuthorKim, Young Dae-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorBaek, Jang Hyun-
dc.contributor.affiliatedAuthorSong, Dong Beom-
dc.contributor.affiliatedAuthorYoo, Joon Sang-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.citation.volume48-
dc.citation.number11-
dc.citation.startPage3138-
dc.citation.endPage3141-
dc.identifier.bibliographicCitationSTROKE, Vol.48(11) : 3138-3141, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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