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Low glycemic index treatment in patients with drug-resistant epilepsy

Authors
 Se Hee Kim  ;  Hoon-Chul Kang  ;  Eun Joo Lee  ;  Joon Soo Lee  ;  Heung Dong Kim 
Citation
 Brain & Development, Vol.39(8) : 687-692, 2017 
Journal Title
 Brain & Development 
ISSN
 0387-7604 
Issue Date
2017
MeSH
Adolescent ; Child ; Drug Resistant Epilepsy/diet therapy* ; Drug Resistant Epilepsy/physiopathology ; Female ; Glycemic Index ; Humans ; Male ; Seizures/diet therapy ; Seizures/physiopathology ; Treatment Outcome
Keywords
Children ; Epilepsy ; Ketogenic diet ; Low glycemic index treatment
Abstract
OBJECTIVE: Low glycemic index treatment (LGIT) is a newly developed dietary therapeutic option for epilepsy that is less restrictive than the ketogenic diet (KD). Our objective was to determine the efficacy and tolerability of LGIT. METHODS: From March 2014 to February 2015, 36 patients received LGIT at Severance Children's Hospital. One-year seizure outcomes and side effects were evaluated. RESULTS: A total of 36 patients were assessed. Fourteen were female. Common diagnoses were Lennox-Gastaut syndrome (33%, 12/36) and Dravet syndrome (14%, 5/36). The median age at the initiation of the LGIT was 12.6years (min.=1.5, max.=28, interquartile range (IQR) 8-17). After 3months of therapy, 20 (56%) patients experienced a 50% or greater reduction in seizure frequency, which was maintained in 19 (53%) patients for 1year. Two (6%) patients became seizure-free after 3months of LGIT; they remained seizure-free for 1year. These two had Dravet syndrome and generalized epilepsy. Only three (8%) patients discontinued treatment within 1year. Adverse events were rare, and two patients (6%) reported transient diarrhea. CONCLUSIONS: LGIT effectively reduced seizure frequency in the present study, although seizure freedom was infrequently achieved. LGIT may be considered as a therapeutic option for patients with drug-resistant epilepsy, particularly those who find KD effective but intolerable.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161120
Full Text
https://www.sciencedirect.com/science/article/pii/S0387760417301043
DOI
10.1016/j.braindev.2017.03.027
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
강훈철(Kang, Hoon Chul) ORCID logo https://orcid.org/0000-0002-3659-8847
김세희(Kim, Se Hee) ORCID logo https://orcid.org/0000-0001-7773-1942
김흥동(Kim, Heung Dong)
이은주(Lee, Eunjoo)
이준수(Lee, Joon Soo)
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