Cited 30 times in
Low glycemic index treatment in patients with drug-resistant epilepsy
DC Field | Value | Language |
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dc.contributor.author | 강훈철 | - |
dc.contributor.author | 김세희 | - |
dc.contributor.author | 김흥동 | - |
dc.contributor.author | 이은주 | - |
dc.contributor.author | 이준수 | - |
dc.date.accessioned | 2018-07-20T08:21:37Z | - |
dc.date.available | 2018-07-20T08:21:37Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0387-7604 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161120 | - |
dc.description.abstract | OBJECTIVE: Low glycemic index treatment (LGIT) is a newly developed dietary therapeutic option for epilepsy that is less restrictive than the ketogenic diet (KD). Our objective was to determine the efficacy and tolerability of LGIT. METHODS: From March 2014 to February 2015, 36 patients received LGIT at Severance Children's Hospital. One-year seizure outcomes and side effects were evaluated. RESULTS: A total of 36 patients were assessed. Fourteen were female. Common diagnoses were Lennox-Gastaut syndrome (33%, 12/36) and Dravet syndrome (14%, 5/36). The median age at the initiation of the LGIT was 12.6years (min.=1.5, max.=28, interquartile range (IQR) 8-17). After 3months of therapy, 20 (56%) patients experienced a 50% or greater reduction in seizure frequency, which was maintained in 19 (53%) patients for 1year. Two (6%) patients became seizure-free after 3months of LGIT; they remained seizure-free for 1year. These two had Dravet syndrome and generalized epilepsy. Only three (8%) patients discontinued treatment within 1year. Adverse events were rare, and two patients (6%) reported transient diarrhea. CONCLUSIONS: LGIT effectively reduced seizure frequency in the present study, although seizure freedom was infrequently achieved. LGIT may be considered as a therapeutic option for patients with drug-resistant epilepsy, particularly those who find KD effective but intolerable. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BRAIN & DEVELOPMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Drug Resistant Epilepsy/diet therapy* | - |
dc.subject.MESH | Drug Resistant Epilepsy/physiopathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycemic Index | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Seizures/diet therapy | - |
dc.subject.MESH | Seizures/physiopathology | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Low glycemic index treatment in patients with drug-resistant epilepsy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Se Hee Kim | - |
dc.contributor.googleauthor | Hoon-Chul Kang | - |
dc.contributor.googleauthor | Eun Joo Lee | - |
dc.contributor.googleauthor | Joon Soo Lee | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.identifier.doi | 10.1016/j.braindev.2017.03.027 | - |
dc.contributor.localId | A00102 | - |
dc.contributor.localId | A00611 | - |
dc.contributor.localId | A01208 | - |
dc.contributor.localId | A05008 | - |
dc.contributor.localId | A03177 | - |
dc.relation.journalcode | J00386 | - |
dc.identifier.eissn | 1872-7131 | - |
dc.identifier.pmid | 28431772 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0387760417301043 | - |
dc.subject.keyword | Children | - |
dc.subject.keyword | Epilepsy | - |
dc.subject.keyword | Ketogenic diet | - |
dc.subject.keyword | Low glycemic index treatment | - |
dc.contributor.alternativeName | Kang, Hoon Chul | - |
dc.contributor.alternativeName | Kim, Se Hee | - |
dc.contributor.alternativeName | Kim, Heung Dong | - |
dc.contributor.alternativeName | Lee, Eunjoo | - |
dc.contributor.alternativeName | Lee, Joon Soo | - |
dc.contributor.affiliatedAuthor | Kang, Hoon Chul | - |
dc.contributor.affiliatedAuthor | Kim, Se Hee | - |
dc.contributor.affiliatedAuthor | Kim, Heung Dong | - |
dc.contributor.affiliatedAuthor | Lee, Eunjoo | - |
dc.contributor.affiliatedAuthor | Lee, Joon Soo | - |
dc.citation.volume | 39 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 687 | - |
dc.citation.endPage | 692 | - |
dc.identifier.bibliographicCitation | BRAIN & DEVELOPMENT, Vol.39(8) : 687-692, 2017 | - |
dc.identifier.rimsid | 61009 | - |
dc.type.rims | ART | - |
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