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Oxytocin receptor gene polymorphisms exert a modulating effect on the onset age in patients with obsessive-compulsive disorder

Authors
 Jee In Kang  ;  Hae Won Kim  ;  Chul Hoon Kim  ;  Eun Hee Hwang  ;  Se Joo Kim 
Citation
 Psychoneuroendocrinology, Vol.86 : 45-52, 2017 
Journal Title
 Psychoneuroendocrinology 
ISSN
 0306-4530 
Issue Date
2017
Keywords
Age at onset ; Genetic association study ; OXTR ; Obsessive-compulsive disorder ; Oxytocin
Abstract
The oxytocin receptor (OXTR) is a potential candidate in the pathophysiology of obsessive-compulsive disorder (OCD). The present study investigated the association between common single-nucleotide polymorphism (SNPs) of the OXTR gene and the affected status of OCD or distinct clinical subtypes of OCD including the age at onset and symptom dimensions. Ten SNPs of OXTR were examined in 615 patients with OCD and 581 healthy controls. Single-marker and haplotype-based association analyses were conducted. While OXTR variants were not associated with the affected status of OCD or its clinical symptom dimensions, rs2268493 (p=0.00185) and rs13316193 (p=0.00461) of the OXTR gene were associated with the age at onset in patients with OCD. In addition, in haplotype-based association analyses, there was a significant association between the OXTR gene and the onset age in patients with OCD. In particular, the G-C-G haplotype of rs2268493-rs2254298-rs11316193 and the T-G-A haplotype of rs237887-rs2268490-rs4686301 were positively associated with late-onset OCD. Our results suggest that common variants of OXTR may exert a modulating effect on the onset age in OCD pathophysiology. The potential involvement of the oxytocin system in the development and expression of OCD warrants further longitudinal research.
Full Text
https://www.sciencedirect.com/science/article/pii/S0306453017304018
DOI
10.1016/j.psyneuen.2017.09.011
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과)
Yonsei Authors
강지인(Kang, Jee In) ORCID logo https://orcid.org/0000-0002-2818-7183
김세주(Kim, Se Joo) ORCID logo https://orcid.org/0000-0002-5438-8210
김철훈(Kim, Chul Hoon) ORCID logo https://orcid.org/0000-0002-7360-429X
김혜원(Kim, Hae Won) ORCID logo https://orcid.org/0000-0002-9321-8361
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161106
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