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Increased Serum Antibody Titer against HPV-16 Antigen in Patients with Behçet's Disease

 Kyu Yeun Kim  ;  Do Young Kim  ;  Jimyung Seo  ;  Yuri Ahn  ;  Dong Soo Kim 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.32(4) : 599-604, 2017 
Journal Title
Issue Date
Adult ; Antibodies, Viral/blood* ; Antigens, Viral/immunology* ; Area Under Curve ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis* ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Human papillomavirus 16/metabolism* ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Odds Ratio ; Papillomavirus Infections/complications* ; Papillomavirus Infections/virology ; ROC Curve
Behçet's Disease ; Enzyme-Linked Immunosorbent Assay ; Human Papilloma Virus ; IgG Antibody
Quadrivalent human papillomavirus (HPV) vaccine has been reported to be significantly associated with Behçet's disease (BD). However, no reports have described HPV infection as a possible cause for the development of BD. The objective of this study was to evaluate whether anti-HPV immunoglobulin G (IgG) antibody titer is increased in BD. Serum samples from 93 Korean BD patients, who fulfilled the diagnostic criteria of the International Study Group for BD, were used in an enzyme-linked immunosorbent assay (ELISA). The clinical activity of BD was evaluated at the time of blood sampling. HPV-16 L1 virus-like particle (VLP) antigen was used in this study for the ELISA. Patients with BD had significantly higher antibody titers against HPV-16 (optical density [OD], 0.210-3.675; mean 0.992) than that of healthy controls (OD, 0.248-0.762; mean 0.517; P < 0.001). Using a receiver operating characteristic (ROC) analysis, a cut-off value of 0.578 OD for the anti-HPV antibody titer was determined that differentiated BD patients from healthy controls. When we compared the clinical features of BD between the 2 groups, articular involvement of BD was more likely in patients with an anti-HPV-16 antibody titer < 0.578 OD (P = 0.035). In addition, patients with an anti-HPV-16 antibody titer < 0.578 were significantly younger than those with a titer ≥ 0.578 OD. HPV itself may be a possible extrinsic triggering infectious agent causing the development of BD.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyu Yeun(김규연)
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
Kim, Dong Soo(김동수)
Seo, Jimyung(서지명)
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