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Histologic purity of signet ring cell carcinoma is a favorable risk factor for lymph node metastasis in poorly cohesive, submucosa-invasive early gastric carcinoma

Authors
 Yon Hee Kim  ;  Ji Hye Park  ;  Cheol Keun Park  ;  Jie-Hyun Kim  ;  Sang Kil Lee  ;  Yong Chan Lee  ;  Sung Hoon Noh  ;  Hyunki Kim 
Citation
 Gastric Cancer, Vol.20(4) : 583-590, 2017 
Journal Title
 Gastric Cancer 
ISSN
 1436-3291 
Issue Date
2017
MeSH
Adult ; Aged ; Carcinoma, Signet Ring Cell/pathology* ; Female ; Gastric Mucosa/pathology ; Humans ; Lymphatic Metastasis/pathology* ; Male ; Middle Aged ; Risk Factors ; Stomach Neoplasms/pathology*
Keywords
Early gastric carcinoma ; Lymph node metastasis ; Pure signet ring cell carcinoma
Abstract
BACKGROUND: The prediction of biologic behavior of poorly cohesive early gastric carcinoma (EGC) is an important issue in the selection of the treatment modality. To elucidate the risk factors for lymph node metastasis (LNM) of poorly cohesive EGC, we focused on the histologic purity of the poorly cohesive component and evaluated the impact of this factor on LNM. METHODS: We divided poorly cohesive EGC into (1) pure signet ring cell (SRC) carcinoma, which was defined as composed only of signet ring cells or poorly cohesive cells and (2) mixed SRC carcinoma, defined as poorly cohesive carcinoma with minor tubular components. We reviewed the clinicopathologic features, including age, sex, location, size, depth, lymphovascular invasion (LVI), LNM, ulceration, and intestinal metaplasia between the two groups in a large series of poorly cohesive, submucosa-invasive EGC (n = 317). RESULTS: LNM was found in 58 cases (18.3 %). Mixed SRC carcinoma histologic type (p < 0.001), larger tumor size (more than 2 cm) (p = 0.012), and the presence of LVI (p < 0.001) were associated with LNM. Pure SRC carcinomas accounted for 56.2 % (178/317) of the cases. Fourteen pure SRC carcinomas (7.8 %) showed LNM, whereas 44 mixed SRC carcinomas (31.9 %) exhibited LNM (p < 0.001). On multivariate logistic regression, the presence of LVI (odds ratio 6.737; 95 % confidence interval 2.714-16.720; p < 0.001) and mixed SRC carcinoma histologic type (odds ratio 4.674; 95 % confidence interval 2.370-9.216; p < 0.001) were independent predictors of LNM in poorly cohesive, submucosa-invasive EGC. CONCLUSIONS: The presence of a tubular component in SRC carcinoma was a risk factor for LNM in poorly cohesive, submucosa-invasive EGC. On the basis of this finding, we propose that the presence of a minor tubular component or the purity of the poorly cohesive/SRC carcinoma component should be reported in daily pathologic practice.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161091
DOI
10.1007/s10120-016-0645-x
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김지현(Kim, Ji Hyun) ; 김현기(Kim, Hyunki) ; 노성훈(Noh, Sung Hoon) ; 이상길(Lee, Sang Kil) ; 이용찬(Lee, Yong Chan)
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Full Text
https://link.springer.com/article/10.1007%2Fs10120-016-0645-x
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