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Increased delta neutrophil index in women with severe preeclampsia

Authors
 Hee Young Cho  ;  Inkyung Jung  ;  So Jung Kim  ;  Yong Won Park  ;  Young Han Kim  ;  Ja‐Young Kwon 
Citation
 American Journal of Reproductive Immunology, Vol.78(3) : e12705, 2017 
Journal Title
 American Journal of Reproductive Immunology 
ISSN
 1046-7408 
Issue Date
2017
MeSH
Adult ; Biomarkers/metabolism* ; Blood Pressure ; Disease Progression ; Female ; Gestational Age ; Headache ; Humans ; Neutrophils/metabolism ; Neutrophils/pathology* ; Pre-Eclampsia/diagnosis* ; Pre-Eclampsia/immunology ; Pregnancy ; Proteinuria ; Retrospective Studies
Keywords
delta neutrophil index ; inflammation ; preeclampsia ; severe
Abstract
PROBLEM: The pathophysiology of preeclampsia (PE) is believed to be associated with a systemic inflammatory response, but few inflammatory markers are currently available to predict PE. Therefore, the aim of this study was to compare the serum delta neutrophil index (DNI) between normal and preeclamptic women. METHODS: Sixty-five patients with mild preeclampsia (mPE), 147 patients with severe preeclampsia (sPE), and 163 women with normal pregnancy were included in this study. Maternal laboratory values including DNI were compared among the three groups. RESULTS: The mean DNI was significantly higher in the sPE group, but there was no significant difference between the normal pregnancy group and mPE. The DNI also showed positive correlation with systolic and diastolic blood pressures, mean arterial pressure, proteinuria during 24 hours, proteinuria in dipstick, and ominous symptoms. CONCLUSION: The serum DNI value was increased in women with severe preeclampsia compared to that in those with normal pregnancy or mild preeclampsia. Further studies are needed to evaluate application of the DNI value as a prognostic marker of preeclampsia.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161065
DOI
10.1111/aji.12705
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실)
Yonsei Authors
권자영(Kwon, Ja Young) ; 김영한(Kim, Young Han) ; 박용원(Park, Yong Won) ; 정인경(Jung, In Kyung)
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Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.12705
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