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Magnetic resonance metabolic profiling of estrogen receptor-positive breast cancer: correlation with currently used molecular markers

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dc.contributor.author구자승-
dc.contributor.author김민정-
dc.contributor.author김은경-
dc.contributor.author박영진-
dc.date.accessioned2018-07-20T08:15:30Z-
dc.date.available2018-07-20T08:15:30Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161019-
dc.description.abstractEstrogen receptor (ER)-positive breast cancers overall have a good prognosis, however, some patients suffer relapses and do not respond to endocrine therapy. The purpose of this study was to determine whether there are any correlations between high-resolution magic angle spinning (HR-MAS) magnetic resonance spectroscopy (MRS) metabolic profiles of core needle biopsy (CNB) specimens and the molecular markers currently used in patients with ER-positive breast cancers. The metabolic profiling of CNB samples from 62 ER-positive cancers was performed by HR-MAS MRS. Metabolic profiles were compared according to human epidermal growth factor receptor 2 (HER2) and Ki-67 status, and luminal type, using the Mann-Whitney test. Multivariate analysis was performed with orthogonal projections to latent structure-discriminant analysis (OPLS-DA). In univariate analysis, the HER2-positive group was shown to have higher levels of glycine and glutamate, compared to the HER2-negative group (P<0.01, and P <0.01, respectively). The high Ki-67 group showed higher levels of glutamate than the low Ki-67 group without statistical significance. Luminal B cancers showed higher levels of glycine (P=0.01) than luminal A cancers. In multivariate analysis, the OPLS-DA models built with HR-MAS MR metabolic profiles showed visible discrimination between the subgroups according to HER2 and Ki-67 status, and luminal type. This study showed that the metabolic profiles of CNB samples assessed by HR-MAS MRS can be used to detect potential prognostic biomarkers as well as to understand the difference in metabolic mechanism among subtypes of ER-positive breast cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMagnetic resonance metabolic profiling of estrogen receptor-positive breast cancer: correlation with currently used molecular markers-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorJi Soo Choi-
dc.contributor.googleauthorDahye Yoon-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorSiwon Kim-
dc.contributor.googleauthorVivian Youngjean Park-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorSuhkmann Kim-
dc.contributor.googleauthorMin Jung Kim-
dc.identifier.doi10.18632/oncotarget.18822-
dc.contributor.localIdA00198-
dc.contributor.localIdA00473-
dc.contributor.localIdA00801-
dc.contributor.localIdA01572-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid28969000-
dc.subject.keywordER-positive-
dc.subject.keywordHR-MAS MRS (high-resolution magic angle spinning magnetic resonance spectroscopy)-
dc.subject.keywordbiomarker-
dc.subject.keywordbreast cancer-
dc.subject.keywordluminal-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Min Jung-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNamePark, Vivian Young Jean-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Min Jung-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorPark, Vivian Youngjean-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume8-
dc.citation.number38-
dc.citation.startPage63405-
dc.citation.endPage63416-
dc.identifier.bibliographicCitationONCOTARGET , Vol.8(38) : 63405-63416, 2017-
dc.identifier.rimsid60910-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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