Cited 9 times in
Magnetic resonance metabolic profiling of estrogen receptor-positive breast cancer: correlation with currently used molecular markers
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김민정 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 박영진 | - |
dc.date.accessioned | 2018-07-20T08:15:30Z | - |
dc.date.available | 2018-07-20T08:15:30Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161019 | - |
dc.description.abstract | Estrogen receptor (ER)-positive breast cancers overall have a good prognosis, however, some patients suffer relapses and do not respond to endocrine therapy. The purpose of this study was to determine whether there are any correlations between high-resolution magic angle spinning (HR-MAS) magnetic resonance spectroscopy (MRS) metabolic profiles of core needle biopsy (CNB) specimens and the molecular markers currently used in patients with ER-positive breast cancers. The metabolic profiling of CNB samples from 62 ER-positive cancers was performed by HR-MAS MRS. Metabolic profiles were compared according to human epidermal growth factor receptor 2 (HER2) and Ki-67 status, and luminal type, using the Mann-Whitney test. Multivariate analysis was performed with orthogonal projections to latent structure-discriminant analysis (OPLS-DA). In univariate analysis, the HER2-positive group was shown to have higher levels of glycine and glutamate, compared to the HER2-negative group (P<0.01, and P <0.01, respectively). The high Ki-67 group showed higher levels of glutamate than the low Ki-67 group without statistical significance. Luminal B cancers showed higher levels of glycine (P=0.01) than luminal A cancers. In multivariate analysis, the OPLS-DA models built with HR-MAS MR metabolic profiles showed visible discrimination between the subgroups according to HER2 and Ki-67 status, and luminal type. This study showed that the metabolic profiles of CNB samples assessed by HR-MAS MRS can be used to detect potential prognostic biomarkers as well as to understand the difference in metabolic mechanism among subtypes of ER-positive breast cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Magnetic resonance metabolic profiling of estrogen receptor-positive breast cancer: correlation with currently used molecular markers | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Ji Soo Choi | - |
dc.contributor.googleauthor | Dahye Yoon | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Siwon Kim | - |
dc.contributor.googleauthor | Vivian Youngjean Park | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.contributor.googleauthor | Suhkmann Kim | - |
dc.contributor.googleauthor | Min Jung Kim | - |
dc.identifier.doi | 10.18632/oncotarget.18822 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A00473 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01572 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 28969000 | - |
dc.subject.keyword | ER-positive | - |
dc.subject.keyword | HR-MAS MRS (high-resolution magic angle spinning magnetic resonance spectroscopy) | - |
dc.subject.keyword | biomarker | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | luminal | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Min Jung | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Park, Vivian Young Jean | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Kim, Min Jung | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Park, Vivian Youngjean | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 38 | - |
dc.citation.startPage | 63405 | - |
dc.citation.endPage | 63416 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.8(38) : 63405-63416, 2017 | - |
dc.identifier.rimsid | 60910 | - |
dc.type.rims | ART | - |
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