Cited 12 times in
Instantaneous pH-Boosted Functionalization of Stellate Gold Nanoparticles for Intracellular Imaging of miRNA
DC Field | Value | Language |
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dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2018-07-20T08:14:10Z | - |
dc.date.available | 2018-07-20T08:14:10Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160997 | - |
dc.description.abstract | Various types of nanoprobes have recently been utilized to monitor living organisms by detecting and imaging intracellular biomarkers, such as microRNAs (miRs). We here present a simple one-pot method to prepare stellate gold nanoparticles functionalized with miR-detecting molecular beacons (SGNP-MBs); low pH conditions permitted the rapid-high loading of MBs on the surface of SGNPs. Compared to the conventional gold nanoparticle-based MBs, SGNPs carried a 4.5-fold higher load of MBs and exhibited a 6.4-fold higher cellular uptake. We demonstrated that SGNP-MBs were successfully internalized in human gastric cancer cell lines and could be used to accurately detect and image intracellular miRs in an miR-specific manner. Furthermore, the relative levels of intracellular miRs in three different cell lines expressing miR-10b (high, moderate, and low levels) could be monitored using SGNP-MBs. Consequently, these results indicated that SGNP-MBs could have applications as highly potent, efficient nanoprobes to assess intracellular miR levels in living cells. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Instantaneous pH-Boosted Functionalization of Stellate Gold Nanoparticles for Intracellular Imaging of miRNA | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Jisun Ki | - |
dc.contributor.googleauthor | Eunji Jang | - |
dc.contributor.googleauthor | Seungmin Han | - |
dc.contributor.googleauthor | Moo-Kwang Shin | - |
dc.contributor.googleauthor | Byunghoon Kang | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1021/acsami.6b16452 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J00004 | - |
dc.identifier.eissn | 1944-8252 | - |
dc.identifier.pmid | 28524648 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsami.6b16452 | - |
dc.subject.keyword | branched gold nanoparticles | - |
dc.subject.keyword | cancer imaging | - |
dc.subject.keyword | miRNA sensing | - |
dc.subject.keyword | molecular beacon | - |
dc.subject.keyword | nanobiosensor | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.citation.volume | 9 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 17702 | - |
dc.citation.endPage | 17709 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, Vol.9(21) : 17702-17709, 2017 | - |
dc.identifier.rimsid | 60889 | - |
dc.type.rims | ART | - |
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