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Instantaneous pH-Boosted Functionalization of Stellate Gold Nanoparticles for Intracellular Imaging of miRNA

DC FieldValueLanguage
dc.contributor.author허용민-
dc.date.accessioned2018-07-20T08:14:10Z-
dc.date.available2018-07-20T08:14:10Z-
dc.date.issued2017-
dc.identifier.issn1944-8244-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160997-
dc.description.abstractVarious types of nanoprobes have recently been utilized to monitor living organisms by detecting and imaging intracellular biomarkers, such as microRNAs (miRs). We here present a simple one-pot method to prepare stellate gold nanoparticles functionalized with miR-detecting molecular beacons (SGNP-MBs); low pH conditions permitted the rapid-high loading of MBs on the surface of SGNPs. Compared to the conventional gold nanoparticle-based MBs, SGNPs carried a 4.5-fold higher load of MBs and exhibited a 6.4-fold higher cellular uptake. We demonstrated that SGNP-MBs were successfully internalized in human gastric cancer cell lines and could be used to accurately detect and image intracellular miRs in an miR-specific manner. Furthermore, the relative levels of intracellular miRs in three different cell lines expressing miR-10b (high, moderate, and low levels) could be monitored using SGNP-MBs. Consequently, these results indicated that SGNP-MBs could have applications as highly potent, efficient nanoprobes to assess intracellular miR levels in living cells.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Chemical Society-
dc.relation.isPartOfACS APPLIED MATERIALS & INTERFACES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleInstantaneous pH-Boosted Functionalization of Stellate Gold Nanoparticles for Intracellular Imaging of miRNA-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorJisun Ki-
dc.contributor.googleauthorEunji Jang-
dc.contributor.googleauthorSeungmin Han-
dc.contributor.googleauthorMoo-Kwang Shin-
dc.contributor.googleauthorByunghoon Kang-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSeungjoo Haam-
dc.identifier.doi10.1021/acsami.6b16452-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ00004-
dc.identifier.eissn1944-8252-
dc.identifier.pmid28524648-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acsami.6b16452-
dc.subject.keywordbranched gold nanoparticles-
dc.subject.keywordcancer imaging-
dc.subject.keywordmiRNA sensing-
dc.subject.keywordmolecular beacon-
dc.subject.keywordnanobiosensor-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.citation.volume9-
dc.citation.number21-
dc.citation.startPage17702-
dc.citation.endPage17709-
dc.identifier.bibliographicCitationACS APPLIED MATERIALS & INTERFACES, Vol.9(21) : 17702-17709, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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