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Triclosan Disrupts SKN-1/Nrf2-Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells

 Dong Suk Yoon  ;  Yoorim Choi  ;  Dong Seok Cha  ;  Peng Zhang  ;  Seong Mi Choi  ;  Mohammad Abdulmohsen Alfhili  ;  Joseph Ryan Polli  ;  DeQwon Pendergrass  ;  Faten A. Taki  ;  Brahmam Kapalavavi  ;  Xiaoping Pan  ;  Baohong Zhang  ;  T. Keith Blackwell  ;  Jin Woo Lee  ;  Myon-Hee Lee 
 SCIENTIFIC REPORTS, Vol.7(1) : 12592, 2017 
Journal Title
Issue Date
Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity in both the nematode C. elegans and human mesenchymal stem cells (hMSCs) by disrupting the SKN-1/Nrf2-mediated oxidative stress response. Specifically, TCS exposure affected C. elegans survival and hMSC proliferation in a dose-dependent manner. Cellular analysis showed that TCS inhibited the nuclear localization of SKN-1/Nrf2 and the expression of its target genes, which were associated with oxidative stress response. Notably, TCS-induced toxicity was significantly reduced by either antioxidant treatment or constitutive SKN-1/Nrf2 activation. As Nrf2 is strongly associated with aging and chemoresistance, these findings will provide a novel approach to the identification of therapeutic targets and disease treatment.
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1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
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