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Triclosan Disrupts SKN-1/Nrf2-Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells

Authors
 Dong Suk Yoon  ;  Yoorim Choi  ;  Dong Seok Cha  ;  Peng Zhang  ;  Seong Mi Choi  ;  Mohammad Abdulmohsen Alfhili  ;  Joseph Ryan Polli  ;  DeQwon Pendergrass  ;  Faten A. Taki  ;  Brahmam Kapalavavi  ;  Xiaoping Pan  ;  Baohong Zhang  ;  T. Keith Blackwell  ;  Jin Woo Lee  ;  Myon-Hee Lee 
Citation
 Scientific Reports, Vol.7(1) : 12592, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity in both the nematode C. elegans and human mesenchymal stem cells (hMSCs) by disrupting the SKN-1/Nrf2-mediated oxidative stress response. Specifically, TCS exposure affected C. elegans survival and hMSC proliferation in a dose-dependent manner. Cellular analysis showed that TCS inhibited the nuclear localization of SKN-1/Nrf2 and the expression of its target genes, which were associated with oxidative stress response. Notably, TCS-induced toxicity was significantly reduced by either antioxidant treatment or constitutive SKN-1/Nrf2 activation. As Nrf2 is strongly associated with aging and chemoresistance, these findings will provide a novel approach to the identification of therapeutic targets and disease treatment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160975
DOI
10.1038/s41598-017-12719-3
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실)
Yonsei Authors
이진우(Lee, Jin Woo)
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