Cited 33 times in
Triclosan Disrupts SKN-1/Nrf2-Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이진우 | - |
dc.date.accessioned | 2018-07-20T08:12:57Z | - |
dc.date.available | 2018-07-20T08:12:57Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160975 | - |
dc.description.abstract | Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupting properties, may pose a risk to early embryonic development and cellular homeostasis during adulthood. Here, we show that TCS induces toxicity in both the nematode C. elegans and human mesenchymal stem cells (hMSCs) by disrupting the SKN-1/Nrf2-mediated oxidative stress response. Specifically, TCS exposure affected C. elegans survival and hMSC proliferation in a dose-dependent manner. Cellular analysis showed that TCS inhibited the nuclear localization of SKN-1/Nrf2 and the expression of its target genes, which were associated with oxidative stress response. Notably, TCS-induced toxicity was significantly reduced by either antioxidant treatment or constitutive SKN-1/Nrf2 activation. As Nrf2 is strongly associated with aging and chemoresistance, these findings will provide a novel approach to the identification of therapeutic targets and disease treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Triclosan Disrupts SKN-1/Nrf2-Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Orthopedic Surgery | - |
dc.contributor.googleauthor | Dong Suk Yoon | - |
dc.contributor.googleauthor | Yoorim Choi | - |
dc.contributor.googleauthor | Dong Seok Cha | - |
dc.contributor.googleauthor | Peng Zhang | - |
dc.contributor.googleauthor | Seong Mi Choi | - |
dc.contributor.googleauthor | Mohammad Abdulmohsen Alfhili | - |
dc.contributor.googleauthor | Joseph Ryan Polli | - |
dc.contributor.googleauthor | DeQwon Pendergrass | - |
dc.contributor.googleauthor | Faten A. Taki | - |
dc.contributor.googleauthor | Brahmam Kapalavavi | - |
dc.contributor.googleauthor | Xiaoping Pan | - |
dc.contributor.googleauthor | Baohong Zhang | - |
dc.contributor.googleauthor | T. Keith Blackwell | - |
dc.contributor.googleauthor | Jin Woo Lee | - |
dc.contributor.googleauthor | Myon-Hee Lee | - |
dc.identifier.doi | 10.1038/s41598-017-12719-3 | - |
dc.contributor.localId | A03230 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 28974696 | - |
dc.contributor.alternativeName | Lee, Jin Woo | - |
dc.contributor.affiliatedAuthor | Lee, Jin Woo | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 12592 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.7(1) : 12592, 2017 | - |
dc.identifier.rimsid | 60868 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.