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Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts the risk of HBV-related liver cancer development

 Seung Up Kim  ;  Ja Yoon Heo  ;  Beom Kyung Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Kwang‐Hyub Han  ;  Sang Hoon Ahn  ;  Hyon‐Suk Kim 
 LIVER INTERNATIONAL, Vol.37(6) : 879-887, 2017 
Journal Title
Issue Date
Adult ; Antigens, Neoplasm/blood ; Biomarkers, Tumor/blood ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/epidemiology ; Elasticity Imaging Techniques ; Female ; Hepatitis B, Chronic/complications ; Humans ; Kaplan-Meier Estimate ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/complications ; Liver Neoplasms/blood ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/epidemiology ; Male ; Membrane Glycoproteins/blood ; Middle Aged ; Multivariate Analysis ; Plant Lectins/blood ; Prognosis ; Receptors, N-Acetylglucosamine/blood ; Republic of Korea/epidemiology ; Retrospective Studies
Mac-2 binding protein ; hepatitis B ; hepatocellular carcinoma ; liver fibrosis
BACKGROUND & AIMS: Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA+ -M2BP) can be used to assess the degree of liver fibrosis, but few studies have investigated its prognostic utility. We evaluated whether serum WFA+ -M2BP can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. METHODS: A total of 1323 CHB patients with WFA+ -M2BP test results between 2009 and 2011 were included in this retrospective analysis. RESULTS: The mean age of patients (793 men) was 51.0 years. During the follow-up period (median 60.3 months), 52 (3.9%) patients developed HCC. Age, the proportion of male gender, the presence of diabetes and cirrhosis, and levels of aspartate aminotransferase, alpha-foetoprotein, and WFA+ -M2BP were significantly greater in patients with HCC than in those without HCC, whereas serum albumin levels and platelet counts were significantly lower in patients with HCC than in those without HCC (all P<.05). In multivariate analysis, WFA+ -M2BP level was an independent predictor of HCC development (adjusted hazard ratio 1.143, 95% CI: 1.139-1.829), along with male gender and diabetes (all P<.05). In patients without cirrhosis (n=1087), WFA+ -M2BP levels ≥1.8 were associated with a higher risk of HCC development (P<.001 by log-rank test), whereas WFA+ -M2BP levels ≥1.8 tended to be associated with a higher risk of HCC development in patients with cirrhosis (n=236) (P=.073 by log-rank test). CONCLUSIONS: WFA+ -M2BP level can independently predict HCC development. Further studies should investigate whether WFA+ -M2BP level could be incorporated into surveillance strategies for CHB patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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