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Antibacterial photodynamic therapy with curcumin and Curcuma xanthorrhiza extract against Streptococcus mutans

Authors
 Hyung-Jung Lee  ;  Si-Mook Kang  ;  Seung-Hwa Jeong  ;  Ki-Ho Chung  ;  Baek-Il Kim 
Citation
 Photodiagnosis and Photodynamic Therapy, Vol.20 : 116-119, 2017 
Journal Title
 Photodiagnosis and Photodynamic Therapy 
ISSN
 1572-1000 
Issue Date
2017
Keywords
Bacteria-related disease ; Caries ; LED ; Natural products ; Photodynamic reaction
Abstract
BACKGROUND: Bacteria are becoming increasingly resistant to conventional antibacterial chemotherapy. This has prompted the application of antibacterial photodynamic therapy (aPDT) in bacteria-related diseases due to its excellent biocide effects. However, few studies have attempted to develop a novel photosensitizer based on natural components. The aim of the present study was to compare the aPDT effects of curcumin and Curcuma xanthorrhiza extract (CXE) against Streptococcus mutans. METHODS: A planktonic suspension containing an S. mutans strain was treated in three separate groups: aPDT with curcumin, CXE, and a mixture of curcumin and CXE (ratio= 1:1) at concentrations of 0, 10, 102, 103, and 104ng/ml. Light irradiation with a center wavelength of 405nm was applied using an LED (power density of 84.5mW for 300s at an energy density of 25.3J/cm2). The phototoxicity of photosensitizers against S. mutans was investigated using a colony-forming-unit assay. Percentage logarithmic reductions [log10(CFU/ml) values] were analyzed using one-way ANOVA followed by the Tukey test (p<0.05) and Student's independent t-test. RESULTS: The viability of S. mutans in the presence of curcumin, CXE, and a mixture of these two components was substantially reduced during irradiation with 405nm light. The phototoxicity of the photosensitizer varied with its solubility and concentration. CONCLUSION: These preliminary in vitro findings imply that combining curcumin and CXE with a 405nm LED may be a novel method of applying aPDT. This could be advantageous in preventing and treating dental caries using devices that are readily available in clinics.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160918
DOI
10.1016/j.pdpdt.2017.09.003
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실)
Yonsei Authors
강시묵(Kang, Si-Mook) ; 김백일(Kim, Baek Il)
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Full Text
https://www.sciencedirect.com/science/article/pii/S1572100017303009
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