0 182

Cited 10 times in

Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma

Authors
 SUNG-IM DO  ;  HYUN-SOO KIM  ;  KYUNGEUN KIM  ;  HYUNJOO LEE  ;  IN-GU DO  ;  DONG-HOON KIM  ;  SEOUNG WAN CHAE  ;  JIN HEE SOHN 
Citation
 ANTICANCER RESEARCH, Vol.37(10) : 5399-5405, 2017 
Journal Title
 ANTICANCER RESEARCH 
ISSN
 0250-7005 
Issue Date
2017
MeSH
Adult ; Aged ; Biomarkers, Tumor/analysis* ; Carcinoma/enzymology* ; Carcinoma/secondary ; Carcinoma, Papillary ; Disease Progression ; Female ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Middle Aged ; Phosphotransferases (Alcohol Group Acceptor)/analysis* ; Predictive Value of Tests ; Prognosis ; Thyroid Neoplasms/enzymology* ; Thyroid Neoplasms/pathology ; Tissue Array Analysis ; Up-Regulation ; Young Adult
Keywords
Thyroid ; immunohistochemistry ; lymph node metastasis ; papillary thyroid carcinoma ; sphingosine kinase 1
Abstract
BACKGROUND/AIM: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. MATERIALS AND METHODS: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples. RESULTS: Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue. Sphingosine kinase 1 was observed in the cytoplasm of tumor cells. Thirty-four (30.9%) of 110 papillary thyroid carcinomas exhibited high sphingosine kinase 1 expression, that was significantly associated with tumor multiplicity (p=0.004), extrathyroidal extension (p=0.013), presence of lymph node metastasis (p<0.001), and number of metastatic lymph nodes (p=0.042). In addition, high sphingosine kinase 1 expression was the only independent predictor of lymph node metastasis (p<0.001). CONCLUSION: Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis.
Full Text
http://ar.iiarjournals.org/content/37/10/5399.long
DOI
10.21873/anticanres.11967
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun-Soo(김현수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160905
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links