Cited 11 times in
Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현수 | - |
dc.date.accessioned | 2018-07-20T08:09:33Z | - |
dc.date.available | 2018-07-20T08:09:33Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160905 | - |
dc.description.abstract | BACKGROUND/AIM: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. MATERIALS AND METHODS: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples. RESULTS: Sphingosine kinase 1 expression in papillary thyroid carcinoma tissue was significantly higher than in nodular goiter (p<0.001) or normal thyroid (p<0.001) tissue. Sphingosine kinase 1 was observed in the cytoplasm of tumor cells. Thirty-four (30.9%) of 110 papillary thyroid carcinomas exhibited high sphingosine kinase 1 expression, that was significantly associated with tumor multiplicity (p=0.004), extrathyroidal extension (p=0.013), presence of lymph node metastasis (p<0.001), and number of metastatic lymph nodes (p=0.042). In addition, high sphingosine kinase 1 expression was the only independent predictor of lymph node metastasis (p<0.001). CONCLUSION: Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Carcinoma/enzymology* | - |
dc.subject.MESH | Carcinoma/secondary | - |
dc.subject.MESH | Carcinoma, Papillary | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phosphotransferases (Alcohol Group Acceptor)/analysis* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Thyroid Neoplasms/enzymology* | - |
dc.subject.MESH | Thyroid Neoplasms/pathology | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.subject.MESH | Up-Regulation | - |
dc.subject.MESH | Young Adult | - |
dc.title | Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | SUNG-IM DO | - |
dc.contributor.googleauthor | HYUN-SOO KIM | - |
dc.contributor.googleauthor | KYUNGEUN KIM | - |
dc.contributor.googleauthor | HYUNJOO LEE | - |
dc.contributor.googleauthor | IN-GU DO | - |
dc.contributor.googleauthor | DONG-HOON KIM | - |
dc.contributor.googleauthor | SEOUNG WAN CHAE | - |
dc.contributor.googleauthor | JIN HEE SOHN | - |
dc.identifier.doi | 10.21873/anticanres.11967 | - |
dc.contributor.localId | A01114 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 28982849 | - |
dc.identifier.url | http://ar.iiarjournals.org/content/37/10/5399.long | - |
dc.subject.keyword | Thyroid | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | lymph node metastasis | - |
dc.subject.keyword | papillary thyroid carcinoma | - |
dc.subject.keyword | sphingosine kinase 1 | - |
dc.contributor.alternativeName | Kim, Hyun-Soo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Soo | - |
dc.citation.volume | 37 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 5399 | - |
dc.citation.endPage | 5405 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.37(10) : 5399-5405, 2017 | - |
dc.identifier.rimsid | 60784 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.