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Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection.

Authors
 Lee H.W.  ;  Choi G.H.  ;  Kim D.Y.  ;  Park Y.N.  ;  Kim K.S.  ;  Choi J.S.  ;  Ahn S.H.  ;  Han K.-H 
Citation
 Oncology, Vol.93(4) : 224-232, 2017 
Journal Title
 Oncology 
ISSN
 0030-2414 
Issue Date
2017
MeSH
Adult ; Aged ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Disease-Free Survival ; Female ; Hepatectomy/mortality ; Hepatectomy/statistics & numerical data ; Hepatitis B/complications ; Hepatitis B/mortality ; Hepatitis B/pathology ; Hepatitis C/complications ; Hepatitis C/mortality ; Hepatitis C/pathology ; Humans ; Liver Cirrhosis/mortality ; Liver Cirrhosis/pathology ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; Prognosis ; Republic of Korea/epidemiology ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
Keywords
Cirrhosis ; Hepatocellular carcinoma ; Surgical resection
Abstract
BACKGROUND: The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. OBJECTIVE: We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. METHODS: We retrospectively examined 649 consecutive patients with HCC who underwent curative resection from 1996 to 2012; 387 (59.6%) were cirrhotic and 262 (40.4%) were noncirrhotic. RESULTS: The mean age was 54.7 years, and 511 (78.7%) of the study participants were men. The most common cause of HCC was hepatitis B virus (n = 419, 64.6%). Noncirrhotic tumors were larger and more advanced than cirrhotic tumors. However, the noncirrhotic group showed better disease-free survival (DFS) and overall survival (OS) after resection than the cirrhotic group (median 64.0 vs. 56.0 months for OS and 48.0 vs. 31.0 months for DFS, p < 0.05). The predictors for HCC recurrence were cirrhosis, tumor number, portal vein invasion, and major surgery. CONCLUSIONS: Noncirrhotic HCC showed better DFS and OS after resection than cirrhotic HCC, although noncirrhotic HCC presented more aggressively.
Full Text
https://www.karger.com/Article/FullText/477173
DOI
10.1159/000477173
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김경식(Kim, Kyung Sik) ORCID logo https://orcid.org/0000-0001-9498-284X
김도영(Kim, Do Young)
박영년(Park, Young Nyun) ORCID logo https://orcid.org/0000-0003-0357-7967
안상훈(Ahn, Sang Hoon) ORCID logo https://orcid.org/0000-0002-3629-4624
이혜원(Lee, Hye Won) ORCID logo https://orcid.org/0000-0002-3552-3560
최기홍(Choi, Gi Hong) ORCID logo https://orcid.org/0000-0002-1593-3773
최진섭(Choi, Jin Sub)
한광협(Han, Kwang-Hyub) ORCID logo https://orcid.org/0000-0003-3960-6539
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160861
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