119 159

Cited 6 times in

RORα2 requires LSD1 to enhance tumor progression in breast cancer

Authors
 Kyeongkyu Kim  ;  Ji Min Lee  ;  Young Suk Yu  ;  Hyunkyung Kim  ;  Hye Jin Nam  ;  Hyeong-Gon Moon  ;  Dong-Young Noh  ;  Keun Il Kim  ;  Sungsoon Fang  ;  Sung Hee Ba다 
Citation
 SCIENTIFIC REPORTS, Vol.7(1) : 11994, 2017 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2017
Abstract
Retinoic acid-related orphan receptor α (RORα) regulates diverse physiological processes, including inflammatory responses, lipid metabolism, circadian rhythm, and cancer biology. RORα has four different isoforms which have distinct N-terminal domains but share identical DNA binding domain and ligand binding domain in human. However, lack of specific antibody against each RORα isoform makes biochemical studies on each RORα isoform remain unclear. Here, we generate RORα2-specific antibody and characterize the role of RORα2 in promoting tumor progression in breast cancer. RORα2 requires lysine specific demethylase 1 (LSD1/KDM1A) as a coactivator for transcriptional activation of RORα2 target genes, exemplified by CTNND1. Intriguingly, RORα2 and LSD1 protein levels are dramatically elevated in human breast cancer specimens compared to normal counterparts. Taken together, our studies indicate that LSD1-mediated RORα2 transcriptional activity is important to promote tumor cell migration in human breast cancer as well as breast cancer cell lines. Therefore, our data establish that suppression of LSD1-mediated RORα2 transcriptional activity may be potent therapeutic strategy to attenuate tumor cell migration in human breast cancer.
Files in This Item:
T201703341.pdf Download
DOI
10.1038/s41598-017-12344-0
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Fang, Sungsoon(황성순) ORCID logo https://orcid.org/0000-0003-0201-5567
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160804
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links