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Tubuloreticular inclusions in peritubular capillaries of renal allografts

 Jee Youn Lee  ;  Seung Hwan Song  ;  Yu Seun Kim  ;  Beom Jin Lim  ;  Soon Il Kim  ;  Myoung Soo Kim  ;  Hyeon Joo Jeong 
 Pathology Research and Practice, Vol.213(9) : 1185-1190, 2017 
Journal Title
 Pathology Research and Practice 
Issue Date
Adult ; Allografts/blood supply ; Allografts/pathology* ; Capillaries/pathology* ; Endothelial Cells/pathology* ; Female ; Graft Rejection/pathology ; Humans ; Inclusion Bodies/pathology* ; Kidney/blood supply ; Kidney/pathology ; Kidney Transplantation* ; Male ; Middle Aged ; Virus Diseases/pathology
Peritubular capillary ; Transplant ; Tubuloreticular inclusion
BACKGROUND: Tubuloreticular inclusions (TRIs) are anastomosing networks of microtubules that are frequently found in autoimmune diseases and viral infections. In renal allografts, TRIs have been reported in glomerular endothelial cells in association with viral infections and donor specific antibodies (DSAs), but their presence in peritubular capillaries has not been explored. METHODS: We collected seven cases with TRIs out of 148 consecutive renal allograft biopsies taken from Dec. 2015 to Dec. 2016. RESULTS: TRIs were present in peritubular capillaries in seven cases and were concomitantly present in glomerular endothelial cells in two cases. The diagnoses included polyomavirus nephropathy (n=2), acute T cell-mediated rejection (ACR) (n=1), combined ACR and antibody-mediated rejection (AMR) (n=1), suspicious for ACR (n=1), chronic active AMR (n=1), and moderate tubular atrophy and interstitial fibrosis (n=1). Six patients had recent or current viral infections (BK polyomavirus, hepatitis B virus, herpes simplex virus, and cytomegalovirus in two, two, one, and one case, respectively). DSA was positive in one case. Five cases had moderate to severe interstitial inflammation and four cases had peritubular capillaritis. CONCLUSION: TRIs are not rare in peritubular capillaries. They are associated with various viral infections and their appearance seems to be related to peritubular capillary injury.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김명수(Kim, Myoung Soo) ORCID logo https://orcid.org/0000-0002-8975-8381
김순일(Kim, Soon Il) ORCID logo https://orcid.org/0000-0002-0783-7538
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
이지연(Lee, Jee Youn)
임범진(Lim, Beom Jin) ORCID logo https://orcid.org/0000-0003-2856-0133
정현주(Jeong, Hyeon Joo) ORCID logo https://orcid.org/0000-0002-9695-1227
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