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Malignancies in Korean patients with immunoglobulin G4-related disease

Authors
 Sung Soo Ahn  ;  Jason Jungsik Song  ;  Yong‐Beom Park  ;  Sang‐Won Lee 
Citation
 International Journal of Rheumatic Diseases, Vol.20(8) : 1028-1035, 2017 
Journal Title
 International Journal of Rheumatic Diseases 
ISSN
 1756-1841 
Issue Date
2017
Keywords
IgG4-related disease ; lymphoma ; malignancy
Abstract
AIM: Several studies have implicated increased risk of malignancy in patients with immunoglobulin G4-related disease (IgG4-RD). Hence, we first evaluated the risk and the type of malignancy in Korean IgG4-RD patients. METHOD: Clinical and laboratory results of patients fulfilling the comprehensive diagnostic criteria for IgG4-RD were retrospectively collected between January 2006 and November 2015. One hundred and eighteen patients were included, and 35 were classified as having definite, 83 as possible/probable IgG4-RD. We compared baseline clinical and laboratory variables between patients with definite and those with possible/probable IgG4-RD and calculated standardized incidence ratios (SIRs) for malignancies. RESULTS: The median age was 60 years old and 91 patients (77.1%) were male. Malignancies were found in 12 of 118 patients (10.1%), and lymphoma (4, 25.0%) was the most frequent malignancy related to IgG4-RD. Definite IgG4-RD patients had higher serum IgG levels and frequent multiple organ involvement. The overall incidence of malignancy was increased in patients with IgG4-RD compared to the general population (SIR 23.08 [95% CI 11.92-40.31]), and the overall risk of SIRs was highest in non-Hodgkin lymphoma (SIR 400.00 [95% CI 109.00-1024.00]). CONCLUSION: Our data showed that increased risk of malignancy, especially lymphomas, was observed in Korean IgG4-RD patients.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13093
DOI
10.1111/1756-185X.13093
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
박용범(Park, Yong Beom)
송정식(Song, Jungsik Jason) ORCID logo https://orcid.org/0000-0003-0662-7704
안성수(Ahn, Sung Soo) ORCID logo https://orcid.org/0000-0002-9002-9880
이상원(Lee, Sang Won)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160740
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