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Sleep Disturbance May Alter White Matter and Resting State Functional Connectivities in Parkinson's Disease

 Seok Jong Chung  ;  Yong-Ho Choi  ;  Hunki Kwon  ;  Yeong-Hun Park  ;  Hyuk Jin Yun  ;  Han Soo Yoo  ;  Seock Hyeon Moon  ;  Byoung Seok Ye  ;  Young H. Sohn  ;  Jong-Min Lee  ;  Phil Hyu Lee 
 SLEEP , Vol.40(3) : zsx009, 2017 
Journal Title
Issue Date
Aged ; Attention/physiology ; Brain Mapping ; Cognition Disorders/physiopathology ; Diffusion Tensor Imaging ; Executive Function/physiology ; Female ; Humans ; Male ; Memory/physiology ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease/complications ; Parkinson Disease/physiopathology* ; Sleep Wake Disorders/complications* ; White Matter/physiopathology*
Parkinson’s disease ; cognition ; functional connectivity ; sleep disturbance ; white matter
Study Objectives: To clarify whether sleep disturbance would alter the patterns of structural and functional networks underlying cognitive dysfunction in patients with Parkinson's disease (PD).

Methods: Among the 180 patients with nondemented PD in our cohort, 45 patients were classified as the group with sleep disturbance according to the 5-item scales for outcomes in Parkinson's disease nighttime scale. Based on propensity scores, another 45 PD patients without sleep disturbance were matched to this group. We performed a comparative analysis of cortical thickness, diffusion tensor imaging-based white matter integrity, resting-state functional connectivity, and cognitive performance between PD patients with and without sleep disturbance.

Results: PD patients with sleep disturbance showed poorer performance in attention and working memory and a tendency toward a lower score in frontal executive function relative to those without sleep disturbance. The PD with sleep disturbance group exhibited widespread white matter disintegration compared to the PD without sleep disturbance group, although there were no significant differences in cortical thickness between the PD subgroups. On functional network analysis, PD patients with sleep disturbance exhibited less severely decreased cortical functional connectivity within the default mode network, central executive network, and dorsal attention network when compared to those without sleep disturbance.

Conclusions: The present study suggests that sleep disturbance in PD patients could be associated with white matter and functional network alterations in conjunction with cognitive impairment.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
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